Primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC), also known as stenotic or occlusive cholangitis, is a relatively rare biliary disease of unknown cause, with a slow course. It is characterized by extensive fibrosis of the bile ducts inside and outside the liver. The wall is significantly thickened and the lumen is significantly narrowed. In addition to obstructive jaundice, clinical manifestations can lead to biliary liver cirrhosis if patients are not diagnosed and treated in time And portal hypertension, and died of liver failure and upper gastrointestinal bleeding. The age of onset is mostly 30 to 50 years, with more men than women. Bacterial and viral infections, immune dysfunction, and certain congenital genetic factors are currently considered possible causes of the disease.

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