Immobilized ciliary syndrome

Immotile cilia syndrome (ICS) is a genetic disease caused by multiple defects in the structure of cilia. It is an autosomal recessive inheritance, including abnormal Kargener syndrome and other monogenic diseases. The incidence is about 1: 30,000 to 1 : 60000. ICS is a genetic defect in the structure of cilia. It is mainly a defect of the ciliary protein arm or radiation, which makes the ciliary movement abnormal, and the cilia on the mucosa clear up and dysfunction, which causes repeated infections. The sperm tail is a special kind of cilia. When its structure is abnormal, sperm loses its motor function, causing infertility. During embryonic development, if the structure of cilia is abnormal, visceral rotation will occur randomly due to the lack of normal cilia swinging; during 10 to 15 days of pregnancy, a left rotation of the viscera instead of a normal right rotation will cause transposition of organs.

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