Renal tubular acidosis

Renal tubular acidosis (RTA) is a metabolic acid that causes congenital genetic defects and various secondary factors to cause proximal tubules to absorb sodium bicarbonate or / and distal renal tubules to drain acid dysfunction. Poisoning. The main manifestations are: ① high chloride, normal anion gap (AG) metabolic acidosis; ② electrolyte disorders; ③ bone disease; ④ urinary tract symptoms. Most patients have no glomerular abnormalities. In some genetic diseases, RTA may be the most important or only clinical manifestation. The diseases in this group are divided into primary and secondary according to the etiology; they are divided into complete and incomplete according to whether systemic metabolic acidosis occurs; they are divided into proximal and distal RTA according to the main renal tubular involvement sites. Currently, a comprehensive classification based on the lesion site, pathophysiological changes and clinical manifestations is used: type 1, distal RTA; type 2, proximal RTA; type 3, which has the characteristics of type 1 and type 2 RTA; type 4, high blood Potassium RTA.

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