Excessive mineralocorticoid secretion

Mineralocorticoid: It mainly acts on sodium, potassium, chloride and water metabolism, so it is called mineralocorticoid. Among these hormones are aldosterone and deoxycorticosterone, among which the action of aldosterone is the strongest. Mineralocorticoids have the effect of preserving sodium and potassium, promoting the reabsorption of sodium by the renal tubules and eliminating potassium, thereby maintaining the proper concentration of sodium and potassium in the plasma. When the adrenal cortex is hyperfunctional (such as Cushing's syndrome) and 11-deoxycorticosterone is excessively secreted, it can cause edema due to the retention of sodium and water in the body beyond the limit, increased blood volume, increased blood pressure, hyperglycemia, hypokalemia Wait. Conversely, if the adrenal cortex is inadequate, the metabolism of sugar and minerals will be disordered, causing bronze disease, or "Addison's disease", showing muscle weakness, decreased blood pressure, skin pigmentation and hypoglycemia, blood Symptoms such as reduced sodium and increased potassium, as well as blood dehydration and concentration, are life-threatening in severe cases.

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