Renal tubular acid dysfunction

Renal tubular acidification dysfunction is similar to type 2 renal tubular acidosis. Renal tubular acidification dysfunction results in renal tubular acidosis. Proximal renal tubular acidosis (PRTA), also known as type Ⅱ renal tubular acidosis, is characterized by: ① most of the glomerular filtered HCO-3 is excreted when the blood bicarbonate (HCO-3) concentration is normal , HCO-3 reabsorption is reduced. ② When the HCO-3 concentration in the blood drops below the patient's HCO-3 renal threshold, there is little HCO-3 excretion in the urine. ③ In severe metabolic acidosis, urine pH can be reduced to a minimum of 5.5 or less, and titratable acids and ammonium can be excreted.

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