Tightness

The tightness of the whole body is one of the clinical symptoms caused by diseases caused by organophosphorus pesticide poisoning. Nicotine-like symptoms in the clinical manifestations of organophosphorus pesticide poisoning: body tightness, slurred speech, chest, upper extremity, face and neck, and whole-body muscle tremor, chest compression, heartbeat frequency, and increased blood pressure when the condition worsens , Severe respiratory paralysis. Organophosphorus pesticides can enter the body through the digestive tract, respiratory tract, and intact skin and mucous membranes. Occupational pesticide poisoning is mainly caused by skin contamination. The absorbed organophosphorus pesticides are distributed in various organs in the body, among which the liver content is the largest, and the brain content depends on the pesticide's ability to penetrate the blood-brain barrier. The main mechanism of organophosphorus pesticide poisoning is inhibition of cholinesterase activity. Organophosphorus is combined with cholinesterase to form phosphorylated cholinesterase, which makes cholinesterase lose the catalytic effect of acetylcholine hydrolysis. Accumulated acetylcholine has two effects on choline nerves: muscarinic effect and nicotine Like effect.

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