Prepubertal amenorrhea

Pre-pubertal amenorrhea: Girls 6-9 years old can detect dehydroepiandrosterone (DHEA) and its sulfates from the urine, which rises rapidly at the age of 10, which is the first manifestation of adrenal function, androgen from the adrenal glands promotes Pubic hair and axillary hair appear, and the body grows quickly because the hypothalamus-pituitary-ovarian axis has not yet been further developed, the level of estrogen is still low, the endometrial proliferation is poor, and bleeding will not be caused. Therefore, menstruation is delayed. The absence of menstrual cramps at this stage before menarche is a physiological phenomenon, and some girls have menstruation once a few months after menarche for a year and a half, and amenorrhea is also normal.

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