Myasthenia gravis

Myasthenia gravis refers to the impairment of the transmission between neuromuscular junctions and the lesions of the muscle fibers themselves, that is, muscle weakness caused by lesions in the presynaptic membrane, synaptic space, postsynaptic membrane, and the muscle fibers themselves. Such as myasthenia gravis, neuromuscular junctions, post-synaptic membrane choline acetate receptors are damaged; when organophosphorus poisoning, cholinesterase activity is affected, making the role of choline acetate excessively prolonged and affecting excitability of muscle cells ; Periodic paralysis is due to changes in membrane potential. Myotonic myopathy is the instability of membrane potentials; muscle phosphorylase deficiency and carnitine palmitate transferase deficiency are due to energy supply obstacles to muscles; muscular dystrophy and polymyositis are both muscle fibers themselves Lesions. Botulinum poisoning and hypermagnesemia affect the entry of calcium into human nerve endings, amino-class drugs block the release of choline acetate, and affect the transmission of presynaptic nerve impulses; American arrowhead toxin and choline acetate receptors bind, thus Affecting the binding of choline acetate and choline acetate receptors can cause muscle weakness.

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