Gradual decline in intelligence after 6 months or 1 year

Amino acid metabolism disease is aminoacidopathy, or aminoaciduria. Can be divided into two categories: one is the enzyme defect, which blocks amino acid catabolism, and the other is the defect of the amino acid absorption and transport system. Of the 48 hereditary amino acid diseases listed by Rosenberg and Scriver, at least half have obvious neurological abnormalities, and the other 20 amino acid diseases cause renal transport defects in amino acids, which can cause secondary neurological damage. Like other hereditary metabolic diseases, amino acid disease does not affect fetal uterine growth, development, or childbirth, and may be early without signs. The main clinical features are normal appearance and activity at birth, progressive decline in intelligence after half a year or one year, and appropriate treatment with amino acid supplements, diet control, and vitamins, and neurological symptoms can be improved in many cases.

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