Urine 6-keto-prostaglandin F1a

Prostaglandin is a group of unsaturated fatty acids consisting of 20 carbon atoms. It was first discovered in semen, so it is called prostaglandin (PG). PG consists of a five-carbon ring structure and two side chains. Its structure is divided into A, B, C, D, E, F, G, H, I and other types. The Arabic numerals in the lower right corner of the letter indicate the number of double bonds contained in the side chain of the PG molecule, such as PGE1 and PGE2. Where the substituents on the five-carbon ring of PG are below the ring plane, they are marked with & alpha ;, such as PGF1 & alpha ;, if they are above the ring plane, they are marked with & beta ;, such as PGF2 & beta ;. Different types of PG have different biological effects. PGE1, PGE2, PGF2 & alpha ;, PGA2, PGI2, TXA2, and TXB2 have been studied more. Among them, prostacyclin (PGI2) and thromboxane (TXA2) are the most widely studied. PG is widely present in various important tissues and body fluids of mammals and humans. It is abundant in blood vessel wall, platelet, lung, kidney, gastrointestinal, brain and reproductive system. The half-life of PG is only 1 to 5 minutes. 6-keto-PGF1 & alpha; is a stable metabolite of PGI2. PG is a type of hormone produced locally and acting locally. The physiological effects of PG are extremely extensive and complex, and various types of PG have completely different effects on different tissues and cells. PG has a certain relationship with cardiovascular, reproductive, central nervous, respiratory, digestive, urinary, platelet function, inflammatory response, immune regulation, and tumor metastasis. PGI2 can dilate blood vessels, reduce peripheral vascular resistance, increase organ blood flow, and have a diuretic and diuretic effect, thereby reducing blood pressure.

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