Cerebrospinal fluid β2-microglobulin

β2-M is a protein composed of a polypeptide chain with a molecular weight of 118 kD. It is synthesized and secreted by normal or malignant hematopoietic, mesenchymal or epithelial cells. The presence of β2-M in cerebrospinal fluid and its increase in concentration indicate that the central nervous system has more severe pathological damage.

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