Adults still look like children

Introduction Pituitary short stature is characterized by short stature and well-proportioned, and looks like a child in adulthood. Pituitary dwarfism refers to growth and development disorders caused by growth hormone deficiency in the anterior pituitary. The only effective treatment for this disease is the replacement of human growth hormone (hGH).

Cause

Clinically divided into idiopathic and secondary, the former is more, accounting for 60-70% of all pituitary dwarfism, the latter due to hypothalamic-pituitary organic lesions, mainly craniopharyngioma , pineal tumors, etc.

an examination

Related inspection

Adrenocorticotropic hormone (ACTH)

1. Growth disorders: After one or two years of birth, the growth gradually slows down, the body is short and well-proportioned, and the appearance after adulthood is still like children, with subcutaneous fat and muscle underdeveloped; the bones are mature, the bone age is younger, and the intelligence is equal to age. .

2. Sexual developmental disorders: male penis is small, cryptorchidism, no beard, tone like a child. Women do not have menstruation, breasts are not developed, the uterus is small, the vulva is childish, and there is no mane.

Differential diagnosis

The appearance of adulthood still looks like a differential diagnosis of children:

1. Cartilage malnutrition: It is a dominant inheritance of chromosomes, mainly due to the formation of chondrocytes in the long bones, which affects the length of the bones, making the bones thicker and not growing. The limbs are short and thick, but the trunk is the principal, so the upper body The length is larger than the lower body, the hips are not but the hips, the fingers are short and short, the fingers are flush, the bridge of the nose is low, the head circumference is large, the forehead is prominent, the abdomen is prominent, the lumbar lordosis, the hip kyphosis is prominent, and the intelligence is normal. The long bone X-ray examination showed that the long bone was short, the curvature was increased, and both ends were swollen.

2, congenital stupid type: also known as Down syndrome, is caused by autosomal abnormalities. The child is often short and small, accompanied by a special face and intelligent backwardness. The nose of the sick child is low, the distance between the two eyes is wide, the outer eye of the two eyes is outward, the mouth is half-length, and the tongue is often extended. The palm print is often continuous, and the little finger is short. Internal curvature, sometimes accompanied by congenital heart disease, chromosome analysis can determine the diagnosis.

3, mucopolysaccharidosis: caused by the congenital mucopolysaccharide metabolism disorder, so that the accumulation of excess mucopolysaccharide in the cells of various tissues in the body. Normal at birth. Symptoms begin from 6 months to 2 years old. The child is short, with low sexual intelligence, thick skin, dry hair, wide eye distance, nose sag, large tongue, often accompanied by hearing impairment, hepatosplenomegaly. The head is large and square, and the fingers are thick and short. X-ray examination showed excessive ossification of the whole body, the saddle was enlarged, and the cranial suture was closed too early. The proximal end of the rib was narrow and the distal end was wide, shaped like a streamer. The urinary mucopolysaccharide increased in children.

4, renal tubular acidosis: is congenital or acquired tubular dysfunction, causing growth retardation in children, accompanied by anorexia, fatigue, weakness, polydipsia, polyuria, polydipsia and so on. X-ray examination showed osteoporosis and osteophyte changes in long bones, calcification in the renal area, blood biochemical metabolism, high blood chlorine, low blood potassium, and alkaline or neutral urine.

5, cretinism: for congenital hypothyroidism or absent, commonly known as stagnation (see endocrine disease, hypothyroidism).

6, familial short stature: related to the family's physical form, although the body length is insufficient, but its growth rate, bone and tooth development, sexual maturity are normal, without any endocrine dysfunction.

8. Growth obstacles: After one or two years of birth, the growth gradually slows down, the body is short and well-proportioned, and the appearance after adulthood is still like children. There are many subcutaneous fats and muscles underdeveloped; the bones are mature, the bone age is younger, intelligence and age. quite.

9. Sexual developmental disorders: male penis is small, cryptorchidism, no beard, tone like a child. Women do not have menstruation, breasts are not developed, the uterus is small, the vulva is childish, and there is no mane.

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