Finger tip and finger (toe) periungual erythema

Introduction Fingertips and nails are a clinical symptom of lupus erythematosus. Lupus erythematosus is one of the autoimmune diseases, which is a range of connective tissue diseases. Lupus erythematosus is classified into discoid lupus erythematosus (DLE), systemic lupus erythematosus (SLE), subacute cutaneous lupus erythematosus, and deep lupus erythematosus. The onset of lupus erythematosus is slow, and insidious attacks occur, and the clinical manifestations are diverse and varied. About 40% of patients have a typical facial erythema called butterfly erythema. In the acute phase, there is edema, bright red, slightly telangiectasia and scaly desquamation. In severe cases, blisters, ulcers, skin atrophy and pigmentation appear.

Cause

The cause of the disease is unknown. Recent studies have confirmed that this disease is characterized by various immune response abnormalities. As for the factors that cause immune disorders, it may be multifaceted.

1. Genetic background.

2, drugs.

3. Infection.

4, physical factors: UV can induce skin lesions or increase the original lesions, a small number of cases can induce or aggravate systemic lesions, about 1/3 SLE patients are allergic to sunlight, Epstein ultraviolet radiation skin type LE patients, about half of cases clinical And histological typical skin lesions.

5, endocrine factors: In view of the fact that women with this disease are significantly more than male, and more in the growth period, it is believed that estrogen is related to the occurrence of this disease.

6, immune abnormalities.

an examination

Related inspection

Rheumatoid associated nuclear antigen (RANA) antibody rheumatoid factor

Clinical manifestations: About 40% of patients have a typical facial erythema called butterfly erythema. In the acute phase, there is edema, bright red, slightly telangiectasia and scaly desquamation. In severe cases, blisters, ulcers, skin atrophy and pigmentation appear. Palm-sized fish, fingertips and fingernails are erythema, and there are maculopapular rashes and purple spots on the exposed parts of the body. A variety of skin lesions accounted for about 80% of the total number of diseases, hair is easy to break, may have alopecia areata.

Differential diagnosis

Osler nodules appear on the fingertips: vasculitis occurs in the subcutaneous arterioles, and can form a purple-red, large-grain, and tenderly nodular nodule on the tip of the finger (toe), called the Osler nodule.

Small granules on the nails: small granules on the nails indicate the symptoms of small granules on the nails.

The central part of the nail is raised: the central part of the bulge refers to the middle part of the nail, and the body is warned. The respiratory system is abnormal. If the protrusion is particularly obvious, it indicates that the liver is defective.

Skinning around the fingernails: It is a lack of vitamin C. Vitamin C deficiency can also cause scurvy. Early symptoms are: temperament, pale skin, indigestion, weakened resistance, etc. In the advanced stage, bone and capillaries are damaged, and in the bones, mainly subperiosteal hemorrhage.

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