Vascular hypersensitivity inflammation

Introduction Allergic vasculitis is one of the most common vasculitis, has been known as leukocyte rupture vasculitis, necrotizing nodular dermatitis, hypersensitivity vasculitis, nodular dermal allergy rash, allergic arteritis and Allergic vasculitis, etc., patients with prominent skin and occasional involvement of other organs. Histopathological examination revealed fibrinous necrosis of the vessel wall and extensive neutrophil infiltration around the vessel. The onset of allergic vasculitis can be anxious to slow down the body's more common symptoms including fever, fatigue, fatigue, etc., local symptoms are mainly skin symptoms, a small number of patients have skin involvement, such as joints, kidneys, lungs, digestive system.

Cause

Causes of vascular allergic inflammation

These exogenous antigens are mainly caused by exogenous antigens and generally include three types:

1. Drugs: including penicillin and its derivatives, sulfa-aspirin and the like.

2. Chemical substances: such as insecticides, herbicides, petroleum preparations.

3. In vitro protein: snake venom serum and various desensitizing agents.

Among the three types of allergens, drugs are the most common.

an examination

Related inspection

Capillary fragility test bone marrow image analysis interleukin 5 (iL-5) urine routine

Laboratory examination

(1) Blood test: blood eosinophils often increase, white blood cell count can be increased, erythrocyte sedimentation rate increases rapidly, hyperglobulinemia and ADP and prostaglandin increase, generally no anemia platelet count is normal, clotting time normal. There is IgG-IgM cryoglobulinemia, laboratory tests show that hyper-gammaemia and hypo-complementemia RF and HBsAg can be positive.

(2) urine test: there may be protein, red blood cells, white blood cells and casts. In severe cases, there may be proteinuria in the range of nephrotic syndrome, and there may be an increase in urea nitrogen and creatinine when renal function is reduced.

(3) routine examination of feces: some patients can see parasite eggs and red blood cells, occult blood test can be positive.

(4) Positive capillary fragility test.

2. X-ray inspection

When the lung is involved, the chest radiograph may show focal or diffuse pulmonary infiltration, or small nodular, occasional pleural effusion.

Differential diagnosis

Vascular allergic inflammation and confusion

Allergic cutaneous vasculitis is an allergic and inflammatory skin disease mainly involving the superficial small blood vessels and capillaries of the dermis. The lesions are pleomorphic, chronic, and often recurrent.

The erythema nodosum is an inflammatory disease that occurs in subcutaneous fat. The acute onset of the disease, the basic lesions are red nodules and plaques, involving the calf extension and thighs, forearms, disappeared after 3 to 6 weeks. The cause is unknown. It is generally believed that vascular delayed allergic reactions caused by bacteria, viruses, fungal infections, tuberculosis or drugs can also be found in certain immune abnormal diseases (such as sarcoidosis, ulcerative colitis and Behcet's disease). The nodular erythema of the tumor-type leprosy reaction is an immune complex vasculitis, so nodular erythema can be regarded as a syndrome or a specific response to various causes.

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