Babies need larger amounts of vitamin B6

Introduction Vitamin B6 includes six interferable pyridoxines, pyridoxamines, pyridoxals, and their respective 5-phosphates. Pyridoxal 5-phosphate is an important part of this group, and it is involved in the metabolism of amino acids, proteins, lipids, nucleic acids and glycogen in the body as a coenzyme of the enzyme system in decarboxylation and transamination. If it is lacking, it can cause convulsions and peripheral nerve diseases. Therefore, vitamin B6 deficiency can cause biochemical and physiological abnormalities. Vitamin B6 dependency syndrome (vitamin B6 dependency syndrome) is a structural and functional defect of the innate metabolic enzyme, kynurenine, whose activity is only 1% of normal. At this time, the amount of vitamin B6 required is 5 to 10 times that required for normal children. Sometimes, because pregnant mothers take large doses of vitamin B6 during the pregnancy reaction period, the baby still needs to rely on a larger amount of vitamin B6 after birth.

Cause

Cause: Vitamin B6 dependency syndrome (vitamin B6 dependency syndrome) is a structural and functional defect of the metabolic enzyme-kynuria, and its activity is only 1% of normal. At this time, the amount of vitamin B6 required is 5 to 10 times that required for normal children. Sometimes, because pregnant mothers take large doses of vitamin B6 during the pregnancy reaction period, the baby still needs to rely on a larger amount of vitamin B6 after birth.

Vitamin B6 includes six interferable pyridoxines, pyridoxamines, pyridoxals, and their respective 5-phosphates. Pyridoxal 5-phosphate is an important part of this group, and it is involved in the metabolism of amino acids, proteins, lipids, nucleic acids and glycogen in the body as a coenzyme of the enzyme system in decarboxylation and transamination. If it is lacking, it can cause convulsions and peripheral nerve diseases. Therefore, vitamin B6 deficiency can cause biochemical and physiological abnormalities.

an examination

Related inspection

Trace element detection in human body

Diagnosis: In case of unexplained convulsions, anemia or chronic diarrhea in infancy, vitamin B6 deficiency or dependence should be considered if hypocalcemia, hypoglycemia, hyponatremia and infectious diseases have been ruled out. The injection of vitamin B6100mg can be used as a basis for diagnosis. The tryptophan load test can be clearly diagnosed. The method is as follows: oral administration of 50-100 mg/kg tryptophan solution (each time does not exceed 2 g), a large amount of scutellaria can occur in the urine of children, and normal people do not have this phenomenon. However, in vitamin B6 dependent patients this test may be negative, serum and red blood cell trough-grass transaminase decreased. The electroencephalogram examines waveforms with abnormal frequency and amplitude changes.

Differential diagnosis

Infants need a larger amount of differential diagnosis of vitamin B6:

Vitamin B6 deficiency: Vitamin B6 deficiency is caused by improper food cooking or too monotonous variety. Malabsorption can also cause vitamin B6 deficiency. Vitamin B6-dependent syndrome is a structural and functional defect in the development of an innate metabolic enzyme, kynurenine. At this time, the requirement of vitamin B6 is 5 to 10 times that required for normal children, and vitamin B6 deficiency is highly prone to occur. . In infants, vitamin B6 deficiency and dependence are mainly manifested by generalized convulsions leading to mental retardation. Also often accompanied by gastrointestinal symptoms such as vomiting, diarrhea and so on. Other manifestations include peripheral neuritis dermatitis and anemia.

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