Lesions yellow to orange

Introduction Skin yellow to orange is one of the symptoms of xanthomatosis. Under normal circumstances, most of the blood lipids bind to plasma proteins to form plasma lipoproteins and transport the whole body. When the blood lipid concentration is higher than the upper limit of normal, it is called hyperlipidemia. When the plasma lipoprotein concentration is higher than the upper limit of normal, it is called high-lipoprotein. Blood. When lipoprotein metabolism is impaired or increased in content or structurally abnormal, it can cause lipoproteins to deposit in tissues, such as xanthomatosis when deposited in skin or tendons.

Cause

Under normal circumstances, most of the blood lipids bind to plasma proteins to form plasma lipoproteins and transport the whole body. When the blood lipid concentration is higher than the upper limit of normal, it is called hyperlipidemia. When the plasma lipoprotein concentration is higher than the upper limit of normal, it is called high-lipoprotein. Blood. When lipoprotein metabolism is impaired or increased in content or structurally abnormal, it can cause lipoproteins to deposit in tissues, such as xanthomatosis when deposited in skin or tendons.

an examination

Related inspection

Blood sugar, blood lipid, blood pressure, triglyceride

According to the relatively solid yellow orange pimples and nodular lesions, yellow tumors can be initially diagnosed. The focus is on distinguishing between primary and secondary primary hyperlipoproteinemia or non-hyperlipoproteinemia xanthomatosis with or without systemic disease, especially cardiovascular, pancreatic, liver endocrine, hematopoietic Systemic lesions are essential for the determination of blood lipids. Histopathology has an auxiliary diagnostic value.

Laboratory inspection:

Mainly to check blood lipids, the examination items should include cholesterol triglyceride, lipoprotein electrophoresis.

Differential diagnosis

Differential diagnosis of skin lesions from yellow to orange:

1. Flat xanthomas: flat papules or plaques that are slightly yellow to orange-yellow than the leather surface, from rice grains to broad beans, with clear boundaries. The most common clinical development occurs around the eyelids, called jaundice, which is common in middle-aged women. It occurs in the upper eyelid sputum, single or multiple, slow development, and can affect the upper and lower eyelids on both sides. A yellow circle around the circumference is very special. This type of xanthoma often does not detect lipid abnormalities if it occurs after the age of 40, and is often associated with hyperlipoproteinemia type II in adolescents. Flattened xanthium is occasionally symmetrical in the periorbital, cervical, trunk, and extremities. It is found in the middle-aged or elderly patients or in patients with various abnormal proteinemias. . The flat yellow tumor can appear as a line along the palmprint and the palm palm surface texture, called palm vein xanthoma, often accompanied by hyperlipoproteinemia type III.

2, nodular xanthomas: from soybeans to walnuts, and even egg-sized papules or nodules, soft, yellowish to orange, and later become solid and brownish red due to fibrosis. Slowly enlarged and fused, it can show lobulated plaques that are significantly higher than the leather surface, with clear boundaries. Occurs in the elbow, knee, knuckle extension, hip, buttocks and other parts. Often accompanied by hyperlipoproteinemia type II, III and IV. Nodular xanthoma can occur in tendons, tendons and fascia, also known as jaundice, more common in the Achilles tendon, deep and solid nodules. More common in patients with severe hyperlipoproteinemia type II and secondary hyperlipoproteinemia.

3, rash yellow tumor: for most needles to the head of the soft small small pimples, initially orange, surrounded by red, then turn yellow brown. Suddenly wholesaled out of the upper torso, buttocks and limbs, and can involve the lips and oral mucosa. Can quickly dissipate without leaving traces. Patients with hyperlipoproteinemia I, V type, occasionally seen in type III or secondary hyperlipoproteinemia.

4, disseminated xanthoma: is a rare normal lipemia non-familial xanthoma, common in young men, for multiple rash small papules and nodules, from orange, red and yellow to mahogany, Heaps are not fused, often symmetrically distributed in the neck, ankle, elbow fossa, groin, fossa and torso flexion. About 1/3 of patients have mucosal damage, which can affect the mouth, nose, throat and even trachea; about 1/3 The patient may involve the hypothalamus and the posterior pituitary gland and cause diabetes insipidus. The course of the disease is chronic but spontaneously relieved.

According to the relatively solid yellow orange pimples and nodular lesions, yellow tumors can be initially diagnosed. The focus is on distinguishing between primary and secondary primary hyperlipoproteinemia or non-hyperlipoproteinemia xanthomatosis with or without systemic disease, especially cardiovascular, pancreatic, liver endocrine, hematopoietic Systemic lesions are essential for the determination of blood lipids. Histopathology has an auxiliary diagnostic value.

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