Pigmented skin and mucous membranes

Introduction Skin and mucous membrane spots are a symptom of multiple gastrointestinal polyp syndrome. Generalized Gastrointestial Polyposis Syndrome refers to the occurrence of multiple polyps in the digestive tract (for young metaplastic or inflammatory polyps), ectodermal abnormalities and severe intermittent A group of syndromes of gastrointestinal and neurological symptoms such as diarrhea, abdominal pain, and numbness of limbs. Invented in 1955 by Crokhite and Canada. It is also known as Cronkhite-Canada syndrome. The age of onset is mostly between 30 and 86 years old, and males are more than females, about 1.5:1.

Cause

The cause is unknown, and no genetic factors have been found. Some people think that it may be related to the lack of delayed type immune response in the small intestine. Pathologically, the gastrointestinal tract has obvious mucosal inflammatory reaction, which is most obvious in the stomach and small intestine. Polyps are most common in the duodenum. The end of the ileum is also more, and the diameter of the polyps can vary from a few millimeters to 3 centimeters. Most scholars believe that polyps are young-type hamartoma-like polyps, and gastric mucosal lesions are similar to Menetriey.

an examination

Related inspection

Blood routine CT examination

The main diagnostic criteria include:

1. Digestive tract symptoms and abnormal ectodermal manifestations of diarrhea and abdominal pain.

2. X-ray tincture gastrointestinal angiography found multiple polyps images.

3. Digestive tract endoscopy revealed diffuse multiple polyps.

Differential diagnosis

The disease should be associated with hereditary gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jegher syndrome), hereditary colon polyp syndrome (Canada syndrome), Turcot syndrome, Gardner syndrome and other gastrointestinal polyposis Identification, these diseases are not accompanied by abnormal changes in ectoderm, which is helpful for identification.

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