Squamous cell metaplasia

Introduction Squamous cell metaplasia refers to local epithelial squamous metaplasia, local squamous epithelial hyperplasia, indicating low-grade squamous intraepithelial lesions, with the possibility of precancerous lesions. It is a cytological examination. Atypical squamous epithelial cells refer to squamous epithelial cells that are not sure of their morphological features and pathological abnormalities. For such patients, attention should be paid to the review, which may be cancerous.

Cause

Many virulence factors can induce many cytopathic factors to induce squamous cell metaplasia, mainly for long-term exposure to ultraviolet light, followed by radiation damage, thermal damage, and carcinogenic chemicals such as arsenic and polycyclic aromatic hydrocarbons. Coal tar, creosote, paraffin, sputum, tobacco tar, chromate, etc. are closely related to the occurrence of squamous cell carcinoma.

an examination

Related inspection

Skin color skin cancer detection physical examination of skin diseases

Microscopic examination: The morphology and structure of tumor cells are the same as those of other squamous cell carcinomas. In the middle and high differentiation, the intercellular bridge and the keratinized beads can be seen; the poorly differentiated keratinization is not obvious, there is no mucous cells, and there is no glandular structure.

Histopathological examination: The tumor consists of irregular epidermal cell masses that proliferate to the dermis. The tumor mass consists of different proportions of normal squamous cells and atypical (metamorphic) squamous cells. Atypical squamous cells vary in size and shape, nuclear proliferation, deep staining, atypical nuclear fission, disappearance of intercellular bridges, local keratinization and pyramidal formation (tumor cells arranged in concentric circles, from surrounding Gradually towards the center is not completely or completely keratinized).

Differential diagnosis

Symptoms of squamous cell metaplasia need to be distinguished from the following symptoms.

Chronic cervicitis: is the most common gynecological disease, especially for married and pregnant women. The disease is often caused by inflammation of the pathogen's invasion of the cervix after childbirth, abortion or surgery. The disease is a long-term chronic change process, not necessarily caused by acute cervicitis. Its clinical manifestations are as follows:

(1) increased vaginal discharge, vaginal discharge is thick or pus, or bloody.

(2) due to the stimulation of leucorrhea caused by genital itching, severe cases may have low back pain and lower abdomen bulge, increased during menstruation or sexual intercourse; may also occur anal pain, frequent urination, dysuria and other difficulties during defecation.

(3) There are many forms of local manifestations of the cervix, such as cervical erosion, cervical hypertrophy, cervical adenitis, cervical polyps, cervicitis, and cervical valgus.

Cervical hypertrophy: due to repeated long-term stimulation of chronic inflammation, resulting in hyperemia of the cervical tissue, edema and connective tissue hyperplasia.

Cervical gland cyst: It is a chronic inflammation of the cervix, which causes the gland and its surrounding tissues to proliferate and block the opening of the gland to form a reservoir cyst called a cervical cyst.

A biopsy of the colposcope, followed by a pathological examination, can confirm the diagnosis of your cervix.

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