Bone marrow megakaryocyte maturation disorder

Introduction The megakaryocyte maturation disorder is often considered to be a typical change in idiopathic thrombocytopenic purpura (ITP) bone marrow examination. In clinical work, connective tissue disease, hypersplenism, and megaloblastic anemia can also be expressed as peripheral platelets. Reduced, bone marrow megakaryocyte maturation is blocked.

Cause

Hypersplenism. Macrophage leukemia. Bone marrow cell hyperplasia. Idiopathic thrombocytopenia.

an examination

Related inspection

Megakaryocyte count, number and classification of bone marrow megakaryocytes

Bone marrow cells proliferate low, hyperplasia is severely low; leukocyte granulocytes are reduced, mainly lobular nucleus, rod-shaped nucleus and late granulocytes, few mesozoic cells; red blood cells of red blood cells are reduced, to young and young red blood cells More obvious, mature red blood cell size, staining, normal morphology; particle red ratio > (normal) reference range, other characteristics: megakaryocyte count decreased, lymphocytes increased, plasma cells also increased. Peripheral blood is reduced in whole blood cells, and lymphocytes are relatively increased.

Differential diagnosis

The symptoms of maturation of bone marrow megakaryocytes need to be distinguished from the symptoms below.

Maturation of the granulocyte deficiency: bone marrow cells proliferate low, active hyperplasia during recovery. Early leukocytes and myelocytes are dominant, and granulocytes in the young, rod-shaped nucleus and lobular nucleus are reduced or even disappeared. Young red blood cells are normal, mainly middle and late red blood cells. The ratio of the particle red to the > (normal) reference range, and the duration of the attack can be < (normal) reference range. Other characteristics of lymphocytes and plasma cells increased relative to the number of white blood cells in the peripheral blood, the number of granulocytes decreased significantly, and lymphocytes increased.

Acute myeloid leukemia: bone marrow cell proliferation is significantly active. Leukocyte granules and promyelocytes are dominant, filamentous mitosis is seen, cell maturation stops, and Auer bodies are visible in the pulp. A few young cells of young red blood cells. The ratio of granule red to <(normal) reference value, other characteristics of megakaryocytes reduced peripheral blood like protozoa and promyelocytes, white blood cell count was significantly increased, normal or decreased in non-leukocytic leukemia.

Chronic myeloid leukemia: Bone marrow cell hyperplasia is extremely active. The white blood cells are extremely increased, and the granulocytes are present in all stages. The young and young and late granulocytes occupy the majority in the following stages, and the filamentous division is easy to see. The young red blood cells have a relatively reduced number of young red blood cells in each stage. Particle red ratio > (normal) reference range Other characteristics of megakaryocytes or (normal) reference values range around the blood can be seen in all stages of granulocytes, acidophilia and basophils.

Acute lymphocytic leukemia: bone marrow cell proliferation is significantly active. Leukocyte prolapse and young lymphocytes account for the majority and abnormal morphology. Young red blood cells are reduced, and young red blood cells are dominant. The grain red ratio is approximately within the (normal) reference value range. Other characteristics of megakaryocytes are reduced, and there are many broken cells. The blood around the bones is the same as the bone marrow.

Chronic lymphocytic leukemia: Bone marrow cell hyperplasia is extremely active. Leukocyte mature lymphocytes are predominant, a few young lymphocytes, and more broken lymphocytes. Young red blood cells are reduced, mainly in young and late red blood cells. The granule red ratio is approximately in the (normal) reference range and other features of megakaryocytes are reduced. The blood around the bones is the same as the bone marrow. Monocytic leukemia: Bone marrow cell proliferation is significantly active. Leukocyte pronuclei, young mononuclear cells, monocytes and pathological mononuclear cells accounted for more than 0.60 (60%). Young red blood cells are reduced. The grain red ratio is approximately in the (normal) reference range. Other features of megakaryocytes are reduced. The blood around the bones is the same as the bone marrow.

Primary thrombocytopenic purpura: bone marrow cells proliferate actively. White blood cells are roughly within the (normal) reference range. The range of reference values for young red blood cells (normal), hyperplasia during acute bleeding. The grain red ratio is approximately in the range of (normal) reference values or reduced. Other features include megakaryocytes, proliferating of progenitor, juvenile and granular megakaryocytes, and rare or absent megakaryocytes producing platelets. The peripheral blood platelet count is reduced.

Multiple myeloma: bone marrow cells proliferate actively. Leukocytes are roughly within the (normal) reference range, often with increased reticuloendothelial cells. Young red blood cells are present in all stages, mainly in young and late red blood cells. Grain red ratio (normal) reference range. Other characteristics of plasma cells increased, and see abnormal plasma cells.

Hypersplenism: bone marrow cells proliferate actively. Leukocyte granulocyte system hyperplasia with maturity disorders. Young red blood cells proliferate with maternal disorders.

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