Anti-endomembrane antibody positive

Introduction Anti-endometrial antibodies (EMAb) are autoantibodies that target the endometrium as a target antigen and cause a series of immune responses. The positive rate of anti-endometrial antibodies in endometriosis and infertile women is significantly higher than that in normal controls. Among the serum of endometriosis, the detection rate of EMAb can reach 70%-80. %. When there is inflammation in the endometrium of women, anti-endometrial antibodies may be converted into antigens or haptens, stimulating the body to produce corresponding antibodies. Infertility caused by anti-endometrial antibody positive is an immune infertility.

Cause

Causes of positive anti-endometrial antibodies:

The first endometrium is ectopic.

Second: inflammation, such as endometritis.

an examination

Related inspection

Endometrial biopsy anti-endothelium autoantibodies

I. Post-sex life test: Within 2 hours after sexual life in the early stage of ovulation, there are 5 sperms that are vigorously advanced in the cervical semen under the high-power field.

Second, serum or cervical mucus anti-sperm antibody positive, or anti-egg zona pellucida antibody positive, or anti-endometrial antibody positive.

Third, statistical processing: the results of the measurement using two and two test methods.

Fourth, the determination method: AsAb determination: ELISA method. See document 1. Serum 1:100, cervical mucus 1:5 dilution. EmAb assay: ELISA method.

V. Specimen collection: All subjects were treated with 2 ml of venous blood, serum was separated, and AsAb and EmAb were determined. 320 swabs of infertile women were treated with sterile cotton swabs (the cotton swab was rotated three times in the cervix). The AsAb was obtained by centrifugation in 1 ml of physiological saline (pregnant woman did not take cervical mucus).

Sixth, microscopic examination: endometrial dysplasia can be seen under electron microscope, vacuoles appear in the intimal gland and basement membrane, and the ratio of cilia to non-ciliated cells decreases. Insufficiency of endometrial secretion is not conducive to implantation of pregnant eggs, leading to infertility and recurrent miscarriage.

Differential diagnosis

Endometrial obstruction: Under normal circumstances, the endometrium covers the surface of the uterine cavity. If the endometrium grows in other parts of the body due to certain factors, it can become endometriosis. This ectopic endometrium has histological not only glandular glands, but also endometrial stroma; functionally with estrogen levels, which vary with the menstrual cycle, but only partially Affected by progesterone, it can produce a small amount of "menstruation" and cause various clinical phenomena.

Endometrial proliferative lesions: Endometrial hyperplasia has a certain tendency to cancer, so it is classified as precancerous lesions. However, according to long-term observation, the vast majority of endometrial hyperplasia is a reversible lesion, or maintain a persistent benign state. Only a few cases may develop cancer after a longer interval. Endometrial hyperplasia is common in middle-aged women over the age of 35. Clinical significance of anti-endometrial antibodies: When artificial abortion cures the uterus, the embryo sac may also act as an antigen to stimulate the body to produce antibodies. It can lead to infertility, stop pregnancy or miscarriage. Many women have induced abortion in the first trimester, and secondary infertility, most of these secondary infertility patients are due to infertility caused by anti-endometrial antibodies in the body.

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