Anti-ovarian antibody positive

Introduction An anti-ovarian antibody is an autoantibody of a target antigen in ovarian granulosa cells, oocytes, luteal cells, and interstitial cells. The production of anti-ovarian antibodies can affect the development and function of ovarian and follicles, leading to premature ovarian failure, irregular menstruation, follicular dysplasia, and even no ovulation to produce anti-fertility effects, leading to infertility. The ovaries produce autoimmune antibodies that often coexist with another autoimmune disease. ,

Cause

1. Chromosomal abnormality Turner's syndrome.

2. Congenital developmental defects: ovarian development or birth defects.

3. Autoimmune diseases: The ovaries produce autoimmune antibodies, often coexisting with another autoimmune disease, such as rheumatoid arthritis, thyroiditis, and myasthenia gravis. Some people used the US method to determine that POF can detect specific antibodies to the ovary and eggs, of which anti-ovarian antibodies accounted for 47%, anti-oval antibodies accounted for 47%, anti-both antibodies were 69%. After immunotherapy, the ovarian antibodies also decreased in two cases of pregnancy.

4. Gene mutation: Animal experiments show that LH unit gene mutation is also a possible factor leading to POF. The genes that may be found related to POF are FSNR, LH, LHR, GHF-QB, FC×LZFMRI, DiADHZ and so on.

5. Physical damage to the ovaries: such as infection (mumps in young children); radiotherapy and chemotherapy in anticancer therapy.

6. Ovariectomy: surgical resection due to cancer or other pregnancy.

7. Others: POF has been caused by ovarian blood supply disorders that have been identified. Some people also mistake POF for non-reactive ovaries, autoimmune diseases and unexplained follicles.

an examination

Related inspection

Ovarian function test ovarian examination luteinizing hormone

1. Non-developed gonads, primary amenorrhea, gonadal dysplasia, delayed menarche or irregular menstruation.

2. Gonadal development is secondary to infertility. After a few years, menstruation is gradually rare until amenorrhea.

3. Ovulation, typical POF has hot flashes, hypogonadal performance, such as night sweats, constipation, hair loss, vaginal dryness, sexual pain, decreased libido, hypothyroidism, urinary tract infection, weight gain, anxiety, suspicious and so on.

Differential diagnosis

Ovarian dysfunction: Ovarian dysfunction is characterized by premature ovarian failure. Definition of premature ovarian failure: The phenomenon of ovarian dysfunction in women before the age of 40, known as premature ovarian failure. The incidence of POF accounts for 1-3% of adult women.

Absence of ovarian or hypoplasia: congenital ovarian hypoplasia, lack of an X chromosome caused by short stature, primary amenorrhea, neck sacral, elbow valgus and other abnormalities. The incidence of this type is much lower than that of the previous type, accounting for 0.64% of female intellectual defects. Its clinical features are female appearance, short body, second characteristic dysplasia, lack of ovaries, and no fertility.

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