Fetal alcohol effects

Introduction Its occurrence may be related to alcohol directly affecting the intrauterine fetus. The placenta of a large number of alcohol-producing mothers has ultrastructural changes that may indirectly affect the fetus and cause fetal dysplasia or deformity. The permanent birth defects caused by the mother's alcohol during pregnancy are affected by the weight, frequency and time of the mother's drinking. Alcohol enters the placenta and impedes the growth and weight of the fetus, causing unique facial plaques, damaging neurons and brain structures, and causing problems such as physical fitness, mentality, or behavior.

Cause

There are three main aspects of the toxicity of ethanol to embryos:

(1) In the middle and late pregnancy, the division, migration and function of the tissues of the fetus, especially the brain tissue, are restricted, and fetal growth retardation and FAE appear.

(2) Direct toxicity damage to early embryonic cell nuclear protein can cause infertility and spontaneous abortion.

(3) In the first 3 months of human pregnancy, it affects the metabolism, differentiation and proliferation of cells, interferes with the occurrence and formation of fetal organs, causes abnormal structure and morphology of multiple organ systems, and causes various types of FAS malformations.

(4) The hyperplasia of the placenta of a large number of alcohol-promoting mothers may affect the fetus indirectly, causing fetal dysplasia or deformity. In addition, fetal alcohol syndrome may also be related to the toxic effects of aldehyde, a metabolite of alcohol oxidation, on cells, leading to developmental disorders of fetal nerve cells.

an examination

Related inspection

Anticardiolipin antibody

Mainly according to the mother's history of alcohol abuse during pregnancy, the child has mental retardation and special face. Prenatal and postpartum, if the child has only part of the syndrome, the diagnosis is more difficult when the mother is a serious drinker. The FAS syndrome, which is not fully developed, is called fetal alcohol, and its incidence is more difficult to determine. Timely liver function, ultrasound monitoring, blood routine, etc.

Differential diagnosis

Fetal Alcohol Syndrome: A serious damage caused by a pregnant woman drinking alcohol, called fetal alcohol syndrome. Low weight, central nervous system developmental disorders, may have microcephaly, face is very strange, forehead protrusion, small eye crack, strabismus, deep bottom of the nose, short nose, nose to the sky, upper lip inward contraction, fan wind ear; Malformations of the heart and limbs. Mainly according to the mother's history of alcohol abuse during pregnancy, the child has mental retardation and special face. Prenatal and postpartum, if the child has only part of the syndrome, the diagnosis is more difficult when the mother is a serious drinker. The FAS syndrome, which is not fully developed, is called fetal alcohol, and its incidence is more difficult to determine.

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