Increase in red blood cell volume

Introduction The red blood cell volume distribution width is increased, which is found in iron deficiency anemia. In particular, when the MCV is still in the reference range, the red blood cell volume distribution width is increased, which is a feature of early iron deficiency anemia. The red blood cell volume distribution width is a parameter reflecting the heterogeneity of the red blood cell volume size, often the coefficient of variation of the measured red blood cell volume size. This is a parameter measured by a blood analyzer that reflects the heterogeneity of peripheral red blood cell volume. In short, it is an objective indicator that reflects the size of red blood cells. Morphological classification of anemia is generally performed by two parameters, RDW and MCV.

Cause

The red blood cell volume distribution width is increased, which is found in iron deficiency anemia. In particular, when the MCV is still in the reference range, the red blood cell volume distribution width is increased, which is a feature of early iron deficiency anemia.

Iron deficiency anemia can occur in the following situations:

First, the demand for iron is increased and the intake is insufficient: in fast-growing infants, children, menorrhagia, pregnant or lactating women, the demand for iron increases, and if the diet is lacking, it is easy to cause iron anemia.

Second, iron malabsorption: iron deficiency anemia due to iron absorption disorders are relatively rare.

Third, blood loss: blood loss, especially chronic blood loss, is the most common and most important cause of iron deficiency anemia. Gastrointestinal hemorrhage such as ulcer disease, cancer, hookworm disease, esophageal varices bleeding, hemorrhoids bleeding, sinusitis after taking salicylate and other diseases that can cause chronic bleeding, women with menorrhagia and hemolytic anemia Iron lutein or hemoglobinuria can cause iron deficiency anemia.

The occurrence of iron deficiency anemia is gradually formed over a long period of time. During the iron depletion period, the stored iron is depleted and the serum ferritin is reduced. There is no anemia at this time, and if the iron deficiency is further aggravated. Storage iron is depleted, serum ferritin and serum iron are decreased, total iron binding capacity is increased, and iron deficiency anemia occurs.

an examination

Generally, there are fatigue, irritability, palpitations, shortness of breath, dizziness, headaches and other performances. Children show growth retardation and lack of concentration. Some patients have gastrointestinal symptoms such as anorexia, heartburn, flatulence, nausea and constipation. A small number of serious patients may have symptoms such as dysphagia, angular cheilitis and glossitis. A professional blood test should be performed to determine the extent and nature of the disease.

Differential diagnosis

1. High hematocrit: Hematocrit helps to understand the increase and decrease of red blood cells. When the absolute value of red blood cells is increased due to various reasons, the hematocrit will also increase accordingly. High hematocrit is found in patients who have been examined for blood after shock.

2, red blood cell malformation: red blood cell malformation in the clinical suggestion for glomerulonephritis, urinary red blood cell morphology examination is a widely used method in clinical application in the past decade. The basic principle is that glomerular-derived red blood cells are affected by mechanical damage of the glomerular basement membrane and/or intra-osseous osmotic gradient, and the morphology is often distorted. The urinary red blood cell morphology of non-glomerular hematuria is generally absent. The above changes occur and show a uniform positive shape. This can help distinguish between glomerular hematuria and non-glomerular hematuria.

3, red blood cells are in the form of money: red blood cells in a string arrangement is the area of exchange of oxygen in the plasma is small, causing blood hypoxia, increased plasma viscosity, slow blood flow, aggravation of systemic tissue oxygen deficiency, making the entire microcirculation a significant obstacle . Generally tired, irritated, palpitations, shortness of breath, dizziness, headache. Children show growth retardation and lack of concentration. Some patients have gastrointestinal symptoms such as anorexia, heartburn, flatulence, nausea and constipation. A small number of serious patients may have difficulty swallowing, angular cheilitis and glossitis.

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