Rhabdomyolysis

Introduction Rhabdomyolysis, also known as myosinuria, refers to the presence of large amounts of muscle protein and myosin in the urine. Myosin itself causes direct damage to the epithelial cells of the renal tubules, and also causes vasoconstriction of the kidney itself; in addition, in the absence of fluid or acidic environment, myosin easily forms crystals in the renal tubules, and Further, the renal tubules are blocked, and thus rhabdomyolysis is likely to cause acute renal failure. The most common clinical symptom of rhabdomyolysis is local or systemic muscle soreness.

Cause

Isoglobin is an iron-containing pigment found in skeletal muscle. When skeletal muscle is destroyed, myoglobin is released into the blood. It will be filtered by the kidneys. Myoglobin may block kidney tissue, leading to acute tubular osteophytes, renal failure and other diseases. Myoglobin breaks down into certain toxic substances, which can also cause kidney failure. Necrotic skeletal muscle produces a large amount of fluid that is transferred to the muscles along with the blood flow, reducing the amount of fluid in the body, which can cause tremors and reduce blood flow to the kidneys. The disease has a combined incidence of 1 in 10,000 and may occur in any age, gender and race. It can happen in any case of damage to the skeletal muscles (especially trauma).

an examination

Related inspection

Urine routine urine color urine analysis urine cytology urine protein

1, muscle pain, weakness, fatigue or tenderness, muscle contraction strength decreased, muscle epidermis may appear swelling and congestion.

2, the urine is oolong tea or cola-like dark brown (this is because the patient has a lot of myosin in the blood and is discharged from the urine).

3. When kidney function is impaired, urine will decrease or even have no urine.

4, urine test paper examination will have occult blood reaction (because the structure of myosin and hemoglobin similar).

Seek medical attention immediately if the above symptoms occur, to avoid damage to the kidneys.

Differential diagnosis

There is a history of the use of drugs that cause rhabdomyolysis and its predisposing factors. Clinical manifestations such as muscle pain, fatigue, muscle spasm, muscle swelling, muscle "water injection" and acute renal failure should be suspected as rhabdomyolysis. Serum CK is 10 times higher than normal; elevated serum myoglobin concentration, no red blood cell soy sauce and myoglobinuria can be diagnosed. Also consider other consolidation factors.

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