Brown urine

Introduction Brown urine means that the color of urine is the same as that of soy sauce or strong tea. This is due to the large amount of free hemoglobin in the urine. There are some children, from around the world, about 100 million children, after eating broad beans, such urine will appear, medically known as broad bean disease. Because these children are born with a lack of an enzyme called -6-GP. If your child has such a condition, you should consider whether you have faba bean disease, and strictly prohibit children from eating broad beans and broad bean products, as well as contact with pollen, because these can induce hemoglobinuria caused by intravascular hemolysis, which is life-threatening.

Cause

Erythrocyte glucose-6-phosphate dehydrogenase (G6PD) has a genetic defect. After eating green fresh beans or exposure to broad bean pollen, acute hemolytic anemia, faba bean disease, occurs, and the pathogenesis is not yet clear. Sensitive red blood cells known to have genetic defects cannot provide sufficient NADPH due to defects in G6PD to maintain the reducing (antioxidation) of reduced glutathione (GSH), which is induced after encountering certain factors of broad bean species. The erythrocyte membrane is oxidized to produce a hemolysis reaction. G-6-PD protects normal red blood cells from oxidative damage. Fresh broad beans are very strong oxidants. When G-6-PD is deficient, red blood cells are destroyed and cause disease.

an examination

Related inspection

Urine routine urine protein test (PRO) nephropathy urine routine blood uric acid

The disease is inherited by sexual association. The G-6-PD gene is on the X chromosome. Most of the patients are male. The ratio of male to female is about 7:1. It takes several hours to several days (1 to 3 days) after eating raw beans. Sudden fever, dizziness, irritability, nausea, urine is soy sauce-like or wine-colored, usually recover after 2 to 6 days, but if the person is not rescued in time, it will endanger life due to circulatory failure. It can be diagnosed by medical history and methemoglobin reduction test (reduction rate greater than 75%), especially by fluorescence point test.

Differential diagnosis

1. Have a history of eating green broad beans or inhaling broad bean pollen.

2. Clinical features:

1 incubation period of several hours to 48 hours.

2 Poisoning performance: early aversion to cold, fever, dizziness, fatigue, loss of appetite, abdominal pain, followed by jaundice, anemia, hemoglobinuria, urine is soy sauce color, after which the body temperature rises, fatigue and fatigue increase, sustainable 3 Around day. 3 experimental examination: methemoglobin reduction test (MHb) normal human reduction rate > 75% (colorimetric method), MHb reduction rate of faba bean disease patients 31% ~ 74% (heterozygous inheritance), reduction rate <30% (homozygous Type); the blood-containing denatured globin body (Hertz body) can be higher than 5% (normally 0 to 0.28%).

Most of the brown urine is due to impaired renal function, resulting in decreased filtration function, hemoglobin in the urine, brown, more common in faba bean disease, it is recommended to go to the hospital for more inspections.

The disease is inherited by sexual association. The G-6-PD gene is on the X chromosome. Most of the patients are male. The ratio of male to female is about 7:1. It takes several hours to several days (1 to 3 days) after eating raw beans. Sudden fever, dizziness, irritability, nausea, urine is soy sauce-like or wine-colored, usually recover after 2 to 6 days, but if the person is not rescued in time, it will endanger life due to circulatory failure. It can be diagnosed by medical history and methemoglobin reduction test (reduction rate greater than 75%), especially by fluorescence point test.

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