Hepatocyte necrosis

Introduction Hepatocyte damage is a common clinical phenomenon. The damage of lethal cells, whether occurring in necrosis or apoptosis, is an irreversible process. Cell necrosis refers to the irreversible loss of metabolic function and structural integrity of the cell serosa, which is characterized by loss of integrity of the serosa. There are many reasons for necrosis. Any factor that can cause damage (hypoxia, physical factors, chemical factors, biological factors, immune reactions, etc.), as long as its effect reaches a certain intensity or for a certain period of time, the metabolism of damaged tissues and cells is completely Stopping can cause local tissue and cell death.

Cause

There are many reasons for necrosis. Any factor that can cause damage (hypoxia, physical factors, chemical factors, biological factors, immune reactions, etc.), as long as its effect reaches a certain intensity or for a certain period of time, the metabolism of damaged tissues and cells is completely Stopping can cause local tissue and cell death. The damage of lethal cells, whether occurring in necrosis or apoptosis, is an irreversible process. Cell necrosis refers to the irreversible loss of metabolic function and structural integrity of the cell serosa, which is characterized by loss of integrity of the serosa. Specific symptoms classification: 1, acute liver necrosis symptoms: nausea, vomiting, liver shrinkage, liver odor, etc.; 2, symptoms of explosive liver necrosis: loss of appetite, nausea, vomiting, jaundice, liver ascites, body bleeding, Hepatic coma, cerebral edema and other symptoms.

an examination

Related inspection

Liver ultrasonography CT examination of liver, gallbladder and spleen

Laboratory examinations must be summarized and analyzed based on objective materials and medical examinations, and several possible diagnostics are proposed, and then further examinations are performed to confirm the diagnosis. For example, measuring liver cell-derived serum transaminase levels can both screen for liver disease and estimate the extent of liver cell damage. Liver ultrasound or CT examination.

Differential diagnosis

Differential diagnosis of hepatocyte necrosis:

1. Hepatitis: Hepatitis (scientific name: Hepatitis) is inflammation of the liver. The causes of hepatitis may vary, the most common being caused by the virus, in addition to autoimmunity. Alcoholism can also cause hepatitis. Hepatitis is divided into acute and chronic hepatitis.

2, liver cancer: liver cancer (liver cancer) is the third most common malignant tumor after death rate of gastric cancer and esophageal cancer. The initial symptoms are not obvious. The late stage is mainly characterized by liver pain, fatigue, weight loss, jaundice and ascites. Clinically, Western medicine is generally used for surgery, radiotherapy and chemotherapy combined with traditional Chinese medicine. However, patients with advanced cancer have a lower cure rate due to the spread of cancer cells. Therefore, early detection, early diagnosis and early treatment of liver cancer should be done. Do a good job in the prevention of liver cancer, adhere to the "pipe water, food management, anti-hepatitis" liver cancer prevention seven-word policy.

3. Liver cirrhosis: Liver cirrhosis is a common chronic liver disease that can cause liver damage by one or more causes. The liver is progressive, diffuse, and fibrous. The specific manifestations are diffuse degeneration and necrosis of hepatocytes, followed by fibrous tissue hyperplasia and hepatocyte nodular regeneration. These three changes are repeatedly staggered. As a result, the hepatic lobular structure and blood circulation pathway are gradually reconstructed, causing the liver to deform and harden. Causes cirrhosis of the liver. There was no obvious symptoms in the early stage of the disease, and a series of different degrees of portal hypertension and liver dysfunction occurred in the later stage until complications such as upper gastrointestinal bleeding and hepatic encephalopathy occurred.

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