Pathological REM sleep

Introduction to pathological REM sleep Pathological REM sleep is characterized by irresistible short-term sleep. The disease is an unclear syndrome characterized by abnormal sleep tendency, including excessive sleepiness during the day, night sleep disturbance, and pathological REM sleep. . More than children or adolescent onset, men and women with similar incidence rates may have a history of encephalitis or craniocerebral trauma. The pathogenesis of this disease is not clear, and may be related to the lowering of the function of the ascending activation system of the brainstem network or the reticular nucleus hyperfunction of the caudal brain. Most patients with other symptoms such as cataplexy, sleep paralysis, sleep hallucinations, etc. Sleeping quadruple syndrome. basic knowledge Sickness ratio: 0.5%-1% Susceptible people: no specific population Mode of infection: non-infectious complication:

Pathological REM sleep etiology

Episodes of sleeping sickness are sleep disorders characterized by paroxysmal irresistible sleep during the day. The prevalence of the disease reported in foreign countries is about 0.2-0.9%, and there is no significant difference in the prevalence of male and female. Most cases start after the age of 10, and about 5% of the cases occur before the age of 10. The disease is closely related to the DQB1 allele HLA-DQB1*0102. The specific cause is unknown and may be related to genetic factors and abnormal sleep mechanisms.

Pathological REM sleep prevention

1. Patients should consciously arrange their life with rich and colorful activities, participate in cultural and sports activities, do some interesting work, and try to avoid monotonous activities.

2, maintain optimistic mood, establish confidence in the fight against disease, avoid depression, sadness, but should not be too excited. Because of the loss of excitement can induce a tripping episode.

3, it is best not to travel alone, do not engage in high-altitude, underwater operations, but also can not engage in driving vehicles, management of various signals and other important work to avoid accidents.

4, patients with paroxysmal sleepiness should try to avoid taking sedative drugs, so as not to increase the incidence.

Pathological REM sleep complications Complication

The disease has no complications.

Pathological REM sleep symptoms common symptoms sleep paralysis baby sleep is not practical sleepiness

The main clinical features of narcolepsy are irresistible sleep, cataplexy, sleep paralysis, and pre-sleeping hallucinations. In addition, patients may have involuntary physical movements during sleep and nighttime restlessness and other symptoms.

Most children with narcolepsy have sudden sleep episodes during the day. The attack can be at school, at a bus, at a dinner table, or while watching TV. There are also some children who suddenly go to sleep while queuing or taking a bath. Although there is a tripping episode in children with narcolepsy, it is not necessary for diagnosis.

Pathological REM sleep examination

Polysomnography shows a shortened sleep latency

Diagnose based on:

According to the transient episode of irresistible sleep or typical symptoms such as stumbling, sleep paralysis, sleep hallucinations, the general diagnosis is not difficult. However, it must be identified with the following diseases.

First, epileptic seizures: more common in children or adolescents, with consciousness disorders as the main symptoms, often sudden loss of consciousness, eye-opening, standing still, not falling; or suddenly terminate the ongoing action, such as holding things, Can not continue the original action, lasted for a few seconds. The electroencephalogram can have a 3 Hz spine-slow integrated wave.

Second, fainting: a transient transient loss of consciousness due to cerebral blood circulation disorders. There are many short signs of dizziness, weakness, nausea, blackness in front of the eyes, and then fainted after loss of consciousness. Often accompanied by autonomic symptoms, such as pale, cold sweat, weak pulse, lower blood pressure, lasting for a few minutes.

Third, Kleine-Levin syndrome: also known as periodic sleepiness and pathological hunger syndrome. Usually seen in male juveniles, with periodic episodes (intervals or weeks), each lasting 3 to 10 days, manifested as lethargy, bulimia and behavioral abnormalities. The etiology and pathogenesis are still unclear, and may be caused by dysfunction of the diencephalon, especially the hypothalamus or focal encephalitis.

Auxiliary inspection:

1. EEG.

2, cerebrospinal fluid cell examination.

3. CT and brain biopsy.

Pathological REM sleep diagnosis

Sleep rhythm disorder: is a regular disorder of sleep caused by diseases such as circadian rhythm sleep disorders and sleep-wake rhythm disorders. Physiological rhythm disorder sleep disorder: persistent or repeated disturbances lead to excessive sleep or insomnia, which is due to the patient's 24-hour sleep-awakening rhythm pattern and the rhythm required by his or her environment. Sleep-wake rhythm disorder refers to the sleep-wake rhythm and the required discrepancy, resulting in persistent dissatisfaction with the quality of sleep. Patients have anxiety or fear, and cause mental activity to decline and impede social function. This disease is not part of any physical illness or mental disorder. If sleep-wake rhythm disorder is an integral part of a physical illness or a mental disorder (such as depression), it is not diagnosed as a sleep-wake rhythm disorder.

Deep sleep disorder: The posterior hypothalamic lesion can cause deep sleep: sleep for several days or weeks, in the middle can be woken up to eat or go to the bathroom, and then sleep again. The hypothalamus weighs about 4g and is small in size. In function, the hypothalamus is the center of neuroendocrine and autonomic regulation of the body. On the whole, the hypothalamus is both a nerve center and an endocrine organ, and is a hub for the nervous system to control the interconnection between endocrine and endocrine organs and internal and external receptors. At least 11 species of secretory hormones have been identified in hypothalamic neurons.

Sleep disorders: abnormal sleep and the appearance of abnormal behavior during sleep. It is also a manifestation of normal rhythmic disorder of sleep and wakefulness.

Sleep paralysis: When a person suddenly dreams of awakening, a part of the nerve center of the brain has awakened, but the nerve center that dominates the muscle has not fully awoke, so although there is an uncomfortable feeling, it is impossible to move.

Polysomnography shows a shortened sleep latency

Diagnose based on:

According to the transient episode of irresistible sleep or typical symptoms such as stumbling, sleep paralysis, sleep hallucinations, the general diagnosis is not difficult. However, it must be identified with the following diseases.

First, epileptic seizures. More common in children or adolescents, with disturbance of consciousness as the main symptom, often sudden loss of consciousness, eye-opening, standing still, not falling; or suddenly ending the ongoing action, such as holding the object, can not continue the original action, It lasts for a few seconds. The electroencephalogram can have a 3 Hz spine-slow integrated wave.

Second, fainted. A transient transient loss of consciousness due to cerebral blood circulation disorders. There are many short signs of dizziness, weakness, nausea, blackness in front of the eyes, and then fainted after loss of consciousness. Often accompanied by autonomic symptoms, such as pale, cold sweat, weak pulse, lower blood pressure, lasting for a few minutes. Third, Kleine-Levin syndrome. Also known as periodic sleepiness and pathological hunger syndrome. Usually seen in male juveniles, with periodic episodes (intervals or weeks), each lasting 3 to 10 days, manifested as lethargy, bulimia and behavioral abnormalities. The etiology and pathogenesis are still unclear, and may be caused by dysfunction of the diencephalon, especially the hypothalamus or focal encephalitis.

Auxiliary inspection:

1. EEG.

2, cerebrospinal fluid cell examination.

3. CT and brain biopsy.

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