Verrucous carcinoma

Introduction to sickle cancer Verrucouscarcinoma was first reported by Ackeman in 1948 as a high-keratinized squamous cell carcinoma. The diagnosis of this disease depends on the clinical, microscopic morphology and biological behavior of this tumor. The tumor grows slowly, initially with exogenous sickle and sputum-like tumors, and finally invades deep tissues. basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: squamous cell carcinoma Condyloma acuminata

Cause of sickle cancer

(1) Causes of the disease

The cause is still unknown.

(two) pathogenesis

The pathogenesis is still unclear.

Verruca cancer prevention

Early detection and early treatment to avoid deterioration.

Verrucous cancer complications Complications squamous cell carcinoma condyloma acuminata

It can invade deep tissues and local lymph node metastasis occurs.

Symptoms of cancer, common symptoms, keratinized nails, tubular squamous cell carcinoma

There are three main types, all occurring in the impregnation zone.

1. verrucous carcinoma of the oral cavity

Also known as oral florid papillomatosis, first reported by Ackeman in 1948, this disease is rare, accounting for only 4% to 9% of oral malignancies, which occurs with tobacco (especially chewing), areca, oral Poor hygiene is associated with inappropriate dental implants. It occurs in male elderly people. The clinical manifestations are white cauliflower-like lesions. The gums can also be affected and can also invade the cheeks and/or jaws.

2. Verrucous carcinoma of the genitoanal region

Also known as Buschke-Loewenstein, the giant condyloma acuminata was first reported by Buschke and Loewenstein in 1925. Most cases were caused by HPV6 or HPV11. This disease accounts for 5% to 25% of penile malignant tumors. It is clinically cauliflower-like papilloma-like hyperplasia. It is most common in male glans and uncircumcised foreskin, and finally invades the urethra. It is also found in the female genital and anal areas. The damage can form ulcers and leaky tubes, often emitting odor.

3. plantar verrucous carcinoma

Also known as epithelioma cuniculatum, the cause is unknown. In the superficial epithelium of 13 reported aneurysms, 5 cases of virus-like particles were found under electron microscope, and the proliferation of nuclear antigens also suggested that the cells were similar. Giant sputum or genital warts, most clinicians believe that this tumor is high-keratinized squamous cell carcinoma, low-dose radiation therapy for chronic infection or inflammation may be related to the occurrence of this disease, the disease is initially very similar to refractory sputum, For the bulging mass, it tends to penetrate deep into the deep, forming a lot of deep crypts, filled with horny matter and pus, the crypt is similar to the rabbit hole, so it is called a perforating epithelioma, and the tumor can finally penetrate the sputum. The fascia can even destroy the bone and invade the skin of the foot.

Examination of sickle cancer

Histopathology: Large and deep biopsy is necessary for the diagnosis of this disease. The superficial part is generally similar to sputum. It is characterized by hyperkeratosis, parakeratosis and acanthosis. The keratinocytes differentiate well and are eosinophilic. The nucleus is small, the tumor is broadly cord-like invading, and the keratin-filled cyst is often found in the center. It is large and bead-shaped. It pushes down the collagen bundle and pushes it to one side, even in the deep part of the tumor. Atypical, individual cells keratinized and angular beads, but some cases, especially the oral cavity, and occasionally verrucous cancer in the genital anal area and the facet, can also show the atypicality of the nucleus and the loss of polarity of the epidermis. In the case of true squamous cell carcinoma, in rare cases, oral, genital and ankle squamous cell carcinoma, local lymph node metastasis can be seen.

Diagnosis and diagnosis of verrucous cancer

The diagnosis of this disease, the important thing is that the biopsy material should be large and deep, in order to observe the whole picture and determine. Clinically, this disease is indistinguishable from classical squamous cell carcinoma and condyloma acuminata. It should also be noted that pseudoepithelial neoplasia should be distinguished, so careful pathological examination is needed.

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