Breast liposarcoma

Introduction to breast liposarcoma Liposarcoma is the most common malignant tumor in soft tissues. The malignant tumor formed by the differentiation of naive mesenchymal cells around the mammary gland into adipocytes is called liposarcomaofbreast. basic knowledge The proportion of the disease: the incidence of this disease in female patients is about 0.05% - 0.08% Susceptible people: women Mode of infection: non-infectious Complications: breast cysts

Causes of breast liposarcoma

Causes:

The cause of this tumor is unknown, and local soft tissue trauma may be a cause.

Pathogenesis:

The disease is mostly derived from the adipose tissue of the breast, and can also be derived from the multi-directional differentiation of the mesenchymal tissue. Therefore, the disease can occur in both fibrous tumors and lobular sarcoma.

1. Gross morphology: The fat sarcoma is lobulated, mostly single, with a diameter of l-20cm. It even invades the whole breast to form a larger mass. The boundary of the mass is clear, the texture is soft, elastic, the cut surface is smooth, sometimes it is glued. Frozen, pale yellow or brownish yellow, often cystic and hemorrhagic necrosis, the tumor has no complete envelope, can infiltrate adjacent tissues, and form some nodules around.

2. Histomorphology: microscopic view of breast liposarcoma is similar to other fatty sarcoma. All types of fat cells contain lipid droplets, but most of them are well-differentiated liposarcoma, while polymorphic spindle cell liposarcoma Rarely, depending on the structure, it can be divided into different types, but sometimes different types can appear in different parts of the same specimen.

(1) lipoma-like liposarcoma: mainly composed of mature fat cells, the cell volume is larger than that of normal fat cells, and a few abnormal nuclei can be seen, which can be doped with astrocytes or spindle cells and mucin-like matrix. This tumor is a more benign "border tumor" that can recur after removal.

(2) well-differentiated mucin-like liposarcoma: This type is mainly composed of fusiform and star-shaped mucoid-like cells, dense capillaries and a large amount of matrix rich in acid mucopolysaccharides, and its cell irregularity is not obvious.

(3) poorly differentiated mucin-like liposarcoma: in addition to visible embryonic and mature adipocytes, there are still a large number of undifferentiated cells, singular giant lipoblasts, lipid-containing mononuclear or multinucleated foam cells. .

(4) pleomorphic liposarcoma: tumor cells have various shapes, such as round, oval, fusiform, etc., and the cell morphology is significant, which is difficult to distinguish from other undifferentiated malignant mesenchymal tumors. Singular lipoblasts containing lipid vacuoles in the cytosol can be found.

Breast liposarcoma prevention

(1) Once you find yourself suffering from fibrocystic breast disease, you should treat it immediately, without delaying the timing of treatment.

(2) For women in lactation, milk should be discharged as much as possible during each breastfeeding process, which can increase the secretion of milk on the one hand and reduce the retention time of the last secreted milk in the breast on the other hand.

(3) Reduce alcohol consumption and alcohol withdrawal. Some Western studies have shown that women with drinking habits are more likely to develop breast cancer than women who do not drink alcohol.

(4) Women with a family history of breast cancer should go to the hospital for a more comprehensive examination in addition to self-examination.

There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.

Breast liposarcoma complications Complications breast cyst

Chronic lactation or secondary cystic cysts may occur due to tumor compression of the breast.

Breast liposarcoma symptoms Common symptoms Breast varicose veins Old men's breasts are not... Breast cancer distant metastasis

Fat sarcoma is single or multiple, located under the skin of the breast, does not adhere to the skin, the epidermis can be completely normal, the size of the tumor is different, the touch is flat or lobulated, the boundary is clear, movable, no pain, when When the tumor grows to a certain extent, it can squash and infiltrate the surrounding tissue. At this time, there may be light tenderness. If the growth is rapid, the local skin may change color and may have varicose veins.

Examination of mammary fat sarcoma

1. Needle aspiration cytology or histopathological biopsy: It can be seen that there are mature fat cells of different sizes in the tumor tissue, and they are heteromorphic, and the cytoplasm may contain lipid vacuoles.

2. Immunohistochemical examination: When it is difficult to distinguish histologically from rhombocytic carcinoma or malignant phyllodes tumor, immunohistochemical staining with S-100 protein can be identified by positive reaction of fat vacuoles in tumor cytoplasm.

Diagnosis and differential diagnosis of breast liposarcoma

diagnosis

There is no difficulty in the diagnosis of this disease. There is no special clinical symptoms in the early stage. It is only a painless mass with soft texture and clear edges. It is easily misdiagnosed as a lipoma. The final diagnosis requires postoperative pathological results.

Differential diagnosis

The tumor cells of this disease are various, and there are many different stages of fat cells in different types of tumor tissues, and they have abnormalities. Therefore, in the well-differentiated lipoma-like sarcoma, more slices should be made, and efforts should be made to find a few significant deformities. The nucleus is differentiated from lipoma and should be distinguished from embryonal rhabdomyosarcoma and polymorphic rhabdomyosarcoma.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.