ceruloplasmin

Cp is a copper-containing glycoprotein that is electrophoretically located between the α1-α2 globulins and is generally classified into the α1 globulin region. One molecule of Cp can be combined with eight copper atoms and is blue, so it is called ceruloplasmin. It is synthesized by the liver, and some of it is excreted from the bile duct, and the amount of urine is very small. The terminal sialic acid of the Cp molecule is linked to the polypeptide and has a genetic polymorphism. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Can be seen in nephrotic syndrome (too much loss), malignant malnutrition, malabsorption, loss of protein gastrointestinal disease, multiple sclerosis, severe anemia, acute hepatitis. Normal value: Urinary ceruloplasmin: 0.006-0.040mg/24h Above normal: Common in acute and chronic inflammatory diseases such as viruses, bacteria, parasites and other infections, as well as rheumatism, rheumatoid arthritis, malignant tumors, aplastic anemia, myocardial infarction, postoperative, etc.; bile duct excretion copper is blocked Biliary cirrhosis; neuropsychiatric diseases (acute schizophrenia, tremor palsy, telangiectasia dysmotility, etc.); bile duct obstruction such as gallstone disease and tumors. negative: Positive: Tips: Try to use fresh morning urine when doing this check. The urine that is randomly selected is preferably mid-stage urine. Menstrual women are not suitable for this examination. Normal value 0.006 ~ 0.040mg / 24h (mean value is 0.056mg / 24h). Clinical significance Abnormal result 1. Increased urine CP level Cp has oxidase activity, which can catalyze the oxidation of Fe2+ to Fe2+ to prevent the formation of lipid peroxides and free radicals, which is of great significance in some pathological conditions. Elevated common in acute and chronic inflammatory diseases such as viruses, bacteria, parasites and other infections, as well as rheumatism, rheumatoid arthritis, malignant tumors, aplastic anemia, myocardial infarction, postoperative, etc.; bile duct excretion of copper Obstructed such as biliary cirrhosis; neuropsychiatric diseases (acute schizophrenia, tremors, telangiectasia, etc.); bile duct obstruction such as gallstones and tumors. Since the Cp-level rise is slower than other glycoproteins such as C-reactive protein, it is classified into the sub-acute phase reactant group. 2, urine Cp reduction can be seen in nephrotic syndrome (too much loss), malignant malnutrition, malabsorption, loss of protein gastrointestinal disease, multiple sclerosis, severe anemia, acute hepatitis. 3, for the differential diagnosis of cirrhosis and liver cancer Cp is significantly elevated in most cases of primary liver cancer, most of the patients with cirrhosis are within the reference value, only a small part is higher than the reference upper limit. 4, diagnosis of hepatolenticular degeneration Hepatolenticular degeneration is a copper metabolic disease, due to genetic defects, the Cp anabolic capacity is reduced, resulting in excessive copper deposition in tissues, especially liver, kidney, brain, cornea Wait. Cp in the blood is significantly reduced. The people who need to be examined have dizziness, palpitation, fatigue, tinnitus, tongue, blood in the stool, cerebral hemorrhage, fever, shortness of breath, chest tightness and other symptoms. Low results may be diseases: high aplastic anemia results may be disease: hepatolenticular degeneration considerations Note during inspection: Fresh morning urine should be used as much as possible during this examination. The urine that is randomly selected is preferably mid-stage urine. Not suitable for the crowd: menstrual women. Inspection process Inspection process: As with routine urine tests, use a clean, dry container with a disposable urine cup and urine test tube provided by the hospital. Take about 10 ml of urine and send it to the designated inspection window of the hospital, and then check it by staining. Not suitable for the crowd Menstrual women. Adverse reactions and risks no.

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