Urea clearance (UCL)

The main function of glomeruli is filtration, and the objective indicator of its filtering function is mainly glomerular filtration rate (GFR). The amount of blood flowing through the kidneys per minute in normal adults is 1200-1400 ml, and the plasma volume is 600-800 ml. After 20% of the plasma is filtered through the glomerulus, the filtrate produced is about 120-160 ml/min. The amount of plasma fluid filtered out by the glomerulus per unit time (minutes) is called the glomerular filtration rate. To determine the glomerular filtration rate, the plasma clearance test of various substances has been designed clinically. . Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: 1, the pathological change clearance rate of 60% to 40%, mild renal damage; 40% to 20%, moderate renal damage; 20% to 5%, severe renal damage; 5% or less, seen in uremic coma. 2. Reflecting the glomerular filtration function. If the Ccr of most acute glomerulonephritis falls below 80% of the normal value, serum BUN and Cr are still in the normal range. Therefore, Ccr is a more sensitive indicator reflecting the glomerular filtration function. Adult Ccr Normal value: Maximum removal rate of urea (Cm): 0.58-0.91ml/(s·m2) Urea standard clearance rate (Cs): 0.36-0.63ml/(s·m2) Above normal: No clinical significance. negative: Positive: Tips: Fresh morning urine should be used as much as possible. The urine that is randomly selected is preferably mid-stage urine. Women should avoid menstruation when taking urine specimens and should prevent vaginal secretions from mixing into the urine. Normal value The maximum removal rate (Cm) of urea is 0.58-0.91 ml/(s·m2) (60-95 ml/min/1.73 m2); the standard clearance rate (Cs) of urea is 0.36-0.63 ml/(s·m2) (40~) 65ml / min / 1.73m2). The urea removal rate is 60% to 125%. Clinical significance 1, the pathological change clearance rate of 60% to 40%, mild renal damage; 40% to 20%, moderate renal damage; 20% to 5%, severe renal damage; 5% or less, seen in uremic coma. 2. Reflecting the glomerular filtration function. If the Ccr of most acute glomerulonephritis falls below 80% of the normal value, serum BUN and Cr are still in the normal range. Therefore, Ccr is a more sensitive indicator reflecting the glomerular filtration function. Adult Ccr <1.3ml / s as a decline in glomerular filtration function, acute glomerulonephritis patients first Ccr decreased, with the condition improved and picked up. Chronic glomerulonephritis showed a progressive decline. 3, preliminary estimates of the degree of damage to renal function, mild damage Ccr is 1.17 ~ 0.85ml / s; moderate damage is 0.83 ~ 0.51ml / s; less than 0.50ml / s is severe damage. Patients with chronic renal failure have early renal failure with Ccr between 0.33 and 0.17 ml/s; advanced renal failure with 10 to 6 ml/min; and end-stage renal failure with less than 5 ml/min. 4, guidance treatment Ccr <0.50 ~ 0.67ml / s should limit protein intake; <0.50ml / thiazide diuretics are often ineffective; <0.33ml / s should be treated with dialysis, for loop diuretics (such as furosemide, The sodium diureate) reaction is also extremely poor. In addition, in renal failure, any drug that is metabolized by the kidney or excreted in the kidney can also adjust the dose and time of administration according to the degree of Ccr reduction. 5, the clinical classification of chronic nephritis, such as chronic nephritis, common Ccr is often reduced, while nephrotic syndrome is due to increased renal tubular basement permeability, Ccr can be excreted from the renal tubules, Ccr no significant change or high. 7. Observing the effect of kidney transplantation The successful Ccr of kidney transplantation is gradually rising, otherwise it is not rising. Acute rejection occurs and falls again. The people who need to be examined have people with symptoms such as edema, high blood pressure, proteinuria, hematuria, and pale face. Low results may be diseases: chronic nephritis, glomerulonephritis precautions Note when checking: 1. Try to use fresh morning urine when doing this test. The urine that is randomly selected is preferably mid-stage urine. 2, women should avoid the menstrual period when taking urine specimens, should prevent vaginal secretions mixed into the urine, middle-stage urine is appropriate. 3. Use a clean and dry container for urine. It is better to use disposable urine cups and urine tubes provided by the hospital. The amount of urine used for routine testing should be about 10 ml and sent for inspection as soon as possible. Inspection process Routine urine test. Not suitable for the crowd Menstrual women. Adverse reactions and risks no.

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