Urinary Hydroxyproline (HYP)

Urinary hydroxyproline can reflect bone resorption and reflect bone formation. Its output is affected by many hormones such as thyroid hormone, growth hormone, adrenocortical hormone and sex hormone. Increased urinary hydroxyproline excretion can be seen in children's growth period, bone destructive diseases (such as hyperthyroidism, bone metastases), bone mineralization diseases (such as rickets, rickets, high conversion osteoporosis, Malformation osteitis). Urinary hydroxyproline has a decreasing trend with increasing age, but the ratio of urinary hydroxyproline to creatinine increases with age. Hydroxyproline is the main component of collagen protein in human connective tissue, accounting for about 10% to 13% of collagen. 50% of the hydroxyproline in the urine comes from bone tissue. Therefore, urinary hydroxyproline excretion can basically reflect changes in bone metabolism, especially with bone resorption rate. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: No clinical significance. Normal value: Urinary hydroxyproline (greater than 21 years old): 114-330μmol/24h Above normal: Hyperparathyroidism, hyperthyroidism, acromegaly, Paget syndrome (abnormal osteitis), osteomalacia, metastatic osteoma, Marfan syndrome, scleroderma, dermatomyositis, progressive Muscular dystrophy, severe burns, postpartum (uterine contraction), and child growth. negative: Positive: Tips: Do not exercise vigorously, maintain a good diet and work. The middle part of the urine is taken for inspection. Normal value 24-hour urinary hydroxyproline excretion can vary with age 1 to 5 years old 150 ~ 496 μmol / 24h (20 ~ 65mg / 24h). 6 to 10 years old 270 ~ 755μmol / 24h (35 ~ 99mg / 24h). 11 to 17 years old 480 ~ 1370μmol / 24h (63 ~ 180mg / 24h). 18 to 21 years old 150 ~ 420μmol / 24h (20 ~ 55mg / 24h). >21 years old 114 ~ 330μmol / 24h (15 ~ 43mg / 24h). The normal value of HYP/Cr is 0.06 to 0.016. Clinical significance Raise Hyperparathyroidism, hyperthyroidism, acromegaly, Paget syndrome (abnormal osteitis), osteomalacia, metastatic osteoma, Marfan syndrome, scleroderma, dermatomyositis, progressive Muscular dystrophy, severe burns, postpartum (uterine contraction), and child growth. People who need to be tested Hyperthyroidism, dermatitis, malnutrition, severe burns. High results may be diseases: precautions for osteoporosis in the elderly Before the test: Do not exercise vigorously, maintain a good diet and rest. At the time of examination: a part of the urine is discharged first to wash away the bacteria remaining in the urethra and the anterior urethra, and then the middle part of the urine is taken for inspection. Inspection process Common clinical measurement methods are 24 urinary hydroxyproline and fasting 2 hours urinary hydroxyproline, and the ratio of urinary hydroxyproline to creatinine. The collagen content in the diet has a greater effect on the 24-hour urinary hydroxyproline content. Therefore, patients should be given a vegetarian diet for 2 to 3 days. The urinary hydroxyproline excretion in the fasting for 2 hours is not affected by the diet, so it can better reflect the basal metabolic status of the patient. Urinary hydroxyproline (HYP) is the main biochemical indicator of bone resorption. It is a product that is not involved in collagen synthesis and is excreted from the urine after decomposition of amino acids and collagen in the bone matrix. Since the discharge amount of HYP is significantly correlated with the bone resorption rate, the bone absorption can be judged by the ratio of urinary hydroxyproline to creatinine (HYP/Cr). HYP/Cr increased with age, and HYP/Cr increased significantly in postmenopausal osteoporosis. During the improvement of osteoporosis, HYP/Cr will gradually decrease. Not suitable for the crowd no. Adverse reactions and risks no.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.