Urine hydroxyproline

Hydroxyproline is a component of collagen, accounting for 13% of its total amino acid. Collagen is the main component of connective tissue and the most abundant protein in the human body. When the connective tissue in the body is proliferated or destroyed, such as Severe fractures, burns, severe tuberculosis and cirrhosis, Hodgkin's disease, hyperthyroidism, and hydroxyproline may cause an increase in hydroxyproline content in blood and urine. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: No clinical significance. Normal value: Urinary hydroxyproline (greater than 21 years old): 114-330μmol/24h Above normal: Hyperparathyroidism, hyperthyroidism, acromegaly, Paget syndrome (abnormal osteitis), osteomalacia, metastatic osteoma, Marfan syndrome, scleroderma, dermatomyositis, progressive Muscular dystrophy, severe burns, postpartum (uterine contraction), and child growth. negative: Positive: Tips: Do not exercise vigorously, maintain a good diet and work. The middle part of the urine is taken for inspection. Normal value 1 to 5 years old 150 ~ 496μmol / 24h (20 ~ 65mg / 24h); 6 to 10 years old 270 ~ 755μmol / 24h (35 ~ 99mg / 24h); 11 to 17 years old 480 ~ 1370μmol / 24h (63 ~ 180mg / 24h); 18 to 21 years old 150 ~ 420μmol / 24h (20 ~ 55mg / 24h); >21 years old 114 ~ 330μmol / 24h (15 ~ 43mg / 24h). Clinical significance Increased hyperparathyroidism, hyperthyroidism, acromegaly, malformation osteitis (Paget syndrome), vitamin D deficiency (osteoma), metastatic osteoma, horse syndrome, hard Skin disease, dermatomyositis and polymyositis (dermatomyositis), progressive muscular dystrophy, severe burns, postpartum (uterine contraction), and child growth. High results may be diseases: osteoporosis in the elderly, progressive bone dysplasia, hyperthyroidism in the elderly, osteogenesis in children, pediatric Caschin-Beck disease, osteogenesis imperfecta, primary myelofibrosis Before the test: Do not exercise vigorously, maintain a good diet and rest. At the time of examination: a part of the urine is discharged first to wash away the bacteria remaining in the urethra and the anterior urethra, and then the middle part of the urine is taken for inspection. Inspection process Common clinical measurement methods are 24 urinary hydroxyproline and fasting 2 hours urinary hydroxyproline, and the ratio of urinary hydroxyproline to creatinine. The collagen content in the diet has a greater effect on the 24-hour urinary hydroxyproline content. Therefore, patients should be given a vegetarian diet for 2 to 3 days. The urinary hydroxyproline excretion in the fasting for 2 hours is not affected by the diet, so it can better reflect the basal metabolic status of the patient. Urinary hydroxyproline (HYP) is the main biochemical indicator of bone resorption. It is a product that is not involved in collagen synthesis and is excreted from the urine after decomposition of amino acids and collagen in the bone matrix. Since the discharge amount of HYP is significantly correlated with the bone resorption rate, the bone absorption can be judged by the ratio of urinary hydroxyproline to creatinine (HYP/Cr). HYP/Cr increased with age, and HYP/Cr increased significantly in postmenopausal osteoporosis. During the improvement of osteoporosis, HYP/Cr will gradually decrease. Not suitable for the crowd no. Adverse reactions and risks no.

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