Plasma 18-hydroxy-corticosterone

Plasma 18-hydroxy-corticosterone is a mineralocorticoid whose secretion function is regulated by both ACTH and renin and angiotensin systems. Its biological effect is mainly sodium and potassium. Basic Information Specialist classification: Oncology examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: In the morning, the standing position was 4 hours, and the apparent decrease was adenoma-type primary aldosteronism. Normal value: Plasma 18-hydroxy-corticosterone (position): 132-318 ng / L Plasma 18-hydroxy-corticosterone (recumbent position 3: 61-137 ng/L) Above normal: The apparent increase was hyperplastic primary aldosteronism. negative: Positive: Tips: taking certain drugs can affect the results of aldosterone determination, such as oral contraceptives, estrogens, furosemide, angiotensin and other drugs can make the test results higher; taking risperidone, dehydrocorticosterone, propranolone Lol, methyldopa and the use of heparin can reduce the measurement results. Normal value Radioimmunoassay Standing position 132 ~ 318ng / L. The lying position (30min) is 61-137ng/L. Clinical significance (1) The increase of 18-OH-B concentration in adenoma-type primary aldosteronism is more pronounced than that of proliferative primary aldosterone. (2) In the morning, the standing position was 4h, and the significantly lowering was adenoma-type primary aldosteronism; the apparently elevated one was proliferative primary aldosteronism. High results may be diseases: precautions for primary aldosteronism (1) Specimens are kept with serum cortisol. However, the diet should control sodium and potassium. The standard diet is: sodium 100mmol/d and potassium 60-100mmol/d. (2) taking certain drugs can affect the results of aldosterone determination, such as oral contraceptives, estrogens, furosemide, angiotensin and other drugs can make the test results higher; taking risperidone, dehydrocorticosterone, propranolone Lol, methyldopa and the use of heparin can reduce the measurement results. (3) Diets that limit sodium and potassium can make the measurement results high. Inspection process Antigen to antibody reaction, B and F separation and radioactivity determination. Not suitable for the crowd People with reduced hematopoietic function such as leukemia, various anemia, myelodysplastic syndrome, or people with thrombocytopenia should pay attention to blood draw, and should not take more or more blood. Adverse reactions and risks 1. After the blood is drawn, do not press the needle hole to avoid subcutaneous hematoma. If there is a small piece of bruise in the blood, it is slightly tender, please don't panic, you can do hot compress after 24 hours to promote the absorption of blood. The general small amount of congestion will gradually absorb in 3 to 5 days and the color will become lighter and return to normal. 2. After the blood draw, symptoms such as dizziness, vertigo, fatigue, etc. should be immediately supine, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.

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