Plasma 17-hydroxyprogesterone (17-OHP)

17α-hydoxyprogesterone (17α-OHP) is produced by the adrenal cortex and gonads, and its progesterone activity is very low. 17α-OHP is 21-hydroxylated to form the precursor compound S (CpS) of cortisol. 17α-OHP has a circadian rhythm change consistent with adrenal cortisol. The concentration of 17α-OHP in adult women of childbearing age varies with the menstrual cycle, and the luteal phase is higher than the follicular phase. The fetus, placenta and adrenal glands produce a large amount of 17α-OHP during pregnancy. The concentration of 17α-OHP increased sharply after 32 weeks of gestation until the delivery period, and 17α-OHP was also present in cord blood of newborns. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: The use of the drug clomiphene can increase the progesterone test results, the use of ampicillin, oral contraceptives can reduce progesterone levels. Normal value Women of childbearing age: follicular phase 0.1 ~ 0.8ng / ml; luteal phase 0.27 ~ 2.9ng / ml; 3 months after pregnancy 3 ~ 12ng / ml. Male: 0.31 to 2.13 ng/ml. Clinical significance Elevated in congenital adrenal hyperplasia, 21-hydroxylase deficiency, 11-hydroxylase deficiency. High results may be diseases: congenital adrenal hyperplasia considerations The use of the drug clomiphene can increase the progesterone test results, using ampicillin, oral contraceptives can reduce progesterone levels. Inspection process Take appropriate plasma and send it for inspection. Gonadal hormone testing. Not suitable for the crowd People with reduced hematopoietic function such as leukemia, various anemia, myelodysplastic syndrome, or people with thrombocytopenia should pay attention to blood draw, and should not take more or more blood. Adverse reactions and risks 1. After the blood is drawn, do not press the needle hole to avoid subcutaneous hematoma. If there is a small piece of bruise in the blood, it is slightly tender, please don't panic, you can do hot compress after 24 hours to promote the absorption of blood. The general small amount of congestion will gradually absorb in 3 to 5 days and the color will become lighter and return to normal. 2. After the blood draw, symptoms such as dizziness, vertigo, fatigue, etc. should be immediately supine, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.

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