erythropoietin

Erythropoietin (EPO) is a glycoprotein produced by the kidneys. EPO may stimulate hematopoietic pluripotent stem cells to form erythroid progenitor cells, but it is also thought to act on erythroid progenitor cells and subsequent cells. In stem cell culture, two types of colonies, blasting erythroid colony forming units (BFU-E) and erythropoietin-reactive colony-forming units (CFU-E), were obtained after the addition of EPO. In fact, EPO has an effect on the cells of the entire red blood cell system. Basic Information Specialist classification: inspection classification: biochemical examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Chronic renal failure. Normal value: EPO (blood coagulation method): 25-75U/L EPO (radioimmunoassay): 5-20U/L Above normal: Anemia, polycythemia, erythropoietinoma, acute leukemia, pheochromocytoma, renal transplant rejection, post-hemorrhage, hypoxemia, pregnancy. negative: Positive: Tips: Strictly check blood pressure, hemoglobin and serum electrolyte changes before examination. Normal value Blood coagulation method 25 ~ 75U / L. Radioimmunoassay 5 ~ 20U / L. Clinical significance Abnormal result (1) elevated anemia, polycythemia, erythropoietinoma, acute leukemia, pheochromocytoma, renal transplant rejection, post-hemorrhage, hypoxemia, pregnancy. (2) reduce chronic renal failure. People who need to be tested Anemia, renal dysfunction, major bleeding, etc. Low results may be diseases: aplastic anemia, pediatric pure red blood cell aplastic anemia, chronic renal anemia high results may be diseases: relative polycythemia, secondary polycythemia, pregnancy with polycythemia, the elderly Polycythemia vera, polycythemia vera, nephroblastoma considerations Before the test: Strictly check blood pressure, hemoglobin and serum electrolyte changes. After the examination: hemoglobin should be checked at least once a week, and the rate of increase should be <20g/L. During the trial period, due to the accelerated synthesis of hemoglobin, attention should be paid to iron, folic acid or vitamin B12. Inspection process It can be injected intravenously or subcutaneously. The dose should be individualized. The general starting dose is 50~100U/kg, 3 times a week. During the treatment, it is necessary to adjust the dose or adjust the maintenance amount depending on the hematocrit or hemoglobin level. Not suitable for the crowd Patients with leukemia and lead poisoning, pregnant women with allergies to this product, patients with epilepsy, cerebral thrombosis. Adverse reactions and risks Nothing.

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