Peak gastric acid secretion assay (PAO)

When the maximum amount of gastric acid secretion was measured, the sum of the two measured values ​​of the highest gastric acid content in the four samples was multiplied by 2, which is the peak gastric acid secretion amount. It is directly related to the size of the cell wall of the gastric mucosa. 5 parts of gastric juice were taken 5 ml respectively, and 2 drops of phenol red indicator were added. Yellow indicates the presence of gastric acid. Titrate to pink with 0.1 mol/L NaOH, and multiply the number of ml of the NaOH solution by 20 to obtain the gastric acid concentration (mmol/L). Gastric acid in the gastric juice (0.2% to 0.4% hydrochloric acid) kills bacteria in the food, ensures the safety of the stomach and intestines, and increases the activity of pepsin to help digestion. Gastric juice plays an important role in digesting food. Normal gastric juice is acidic. It is 20~100ml on fasting. More than 100ml indicates increased gastric acid secretion. There is a certain amount of gastric secretion, such as excessive secretion, it will appear acid, nausea, vomiting acid and so on. Basic Information Specialist classification: Digestive examination classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: After duodenal ulcer surgery, the reduction after partial gastrectomy. Normal value: PAO: 12.23-28.97mmol/h Above normal: Duodenal ulcer and complex ulcer. negative: Positive: Tips: Avoid spicy food. Normal value The amount of basal gastric juice is 10 to 100 ml; PAO is 20.60 ± 8.77 mmol/h. (Note the specific reference value depends on each laboratory.) Clinical significance BDU and PAO increased in duodenal ulcer and complex ulcer, BAO>5mmol/h has diagnostic significance; if PAO>40mmol/h, it suggests that blood or perforation will be emitted. BAO and PAO decreased significantly after duodenal ulcer, and BAO and PAO decreased significantly after partial gastrectomy. If anastomotic ulcer appeared after operation, the two increased gradually. The pH>7 of the pentapeptide gastrin gastric acid secretion test is true gastric acid deficiency; if the pH is between 3.5 and 7.0, the gastric acid is too low; the gastric cancer and atrophic gastritis may be true gastric acid deficiency. Zhuoai syndrome (gastrinoma) BAO>15mmoL/h, MAO>30mmol/h, BAO/MAO ratio, often >0.6, so the pentapeptide gastrin test has been used as a diagnostic basis. High results may be diseases: duodenal ulcer, superficial gastritis precautions (1) 0.1mol/L NaOH solution should be prepared according to the requirements of quantitative analysis. (2) The gastric juice specimens must be extracted strictly according to the regulations. They should be punctual, and each time they should be exhausted, the collection should be accurate and promptly sent for inspection. (3) If gastric acid is reduced to determine gastric acid, the NaOH solution should also be diluted accordingly. (4) 5 × 107 gastric parietal cells can produce 1 mmol/L hydrochloric acid per hour, and the number of gastric parietal cells can be estimated according to PAO. Inspection process Gastric tube collection method: 1. The action should be light when intubating, and do not damage the esophageal mucosa. You should be proficient in the depth and method of intubation. 2, if there is cough, difficulty breathing, cyanosis, etc. during the intubation process, suggesting that the trachea is mistaken. It should be pulled out immediately, and then rested after a short break. 3. After insertion, check if the stomach tube is in the stomach by the following method (1) Connect the end of the stomach tube to the syringe. If the gastric juice can be withdrawn, the stomach tube is proved to be in the stomach. (2) Inject 10 ml of air from the stomach tube with a syringe, and use a stethoscope to pick up the gas over water in the stomach, indicating that the stomach tube is in the stomach. (3) Place the open end of the stomach tube under the water surface, and insert the airway into the trachea if the patient escapes when exhaling. 5 parts of gastric juice were taken 5 ml respectively, and 2 drops of phenol red indicator were added. Yellow indicates the presence of gastric acid. Titrate to pink with 0.1 mol/L NaOH, and multiply the number of ml of the NaOH solution by 20 to obtain the gastric acid concentration (mmol/L). Not suitable for the crowd Any esophageal varices, esophageal stenosis, esophageal tumor, aortic aneurysm, severe hypertension, cardiovascular disease, heart failure, late pregnancy, physical weakness and other serious diseases should not be inserted into the stomach tube. Adverse reactions and risks If coughing, difficulty breathing, cyanosis, etc. occur during intubation, it is suggested to enter the trachea. It should be pulled out immediately, and then rested after a short break.

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