tumor suppressor gene Rb

The tumor suppressor gene Rb gene is the first cloned tumor suppressor gene, which was first discovered in children's retinoblestoma, so it is called Rb gene. The Rb gene is located on human chromosome 13 q14, which is 200kb in length. 27 exons, 26 introns, encoding 928 amino acid residues (p105). The anticancer activity of Rb gene has two meanings. One is that Rb protein inhibits cell growth in normal cells; the other is that Rb gene inhibits growth and tumorigenicity in tumor cells. Basic Information Specialist classification: Oncology examination classification: immune examination Applicable gender: whether men and women apply fasting: fasting Tips: Check the spicy dry food before the test, affect the blood test, and taboo drugs. Observe the doctor's request and do a good blood sample. Normal value There was no deletion of the Rb gene, and the presence of the Rb gene was detected and negatively expressed. Clinical significance Abnormal results using Rb gene and anti-Rb protein antibodies to detect normal human tissues and their corresponding tumor tissues, found that the structure and expression of Rb gene in normal human tissues are normal, and the corresponding gene deletion mutations in tumor tissues, lack of normal Rb protein. Human Rb gene was introduced into cancer cells such as retinoblastoma, bladder cancer, and lung cancer by retroviral infection. As a result, Rb gene can inhibit the carcinogenicity of these cancer cell lines in nude mice to varying degrees. These results provide direct evidence for the anti-cancer properties of the Rb gene. People with low immunity in the population to be examined usually have pancreatic cancer, bladder cancer, stomach cancer, esophageal cancer, bone cancer and other people to check, especially the elderly and smokers. Positive results may be diseases: precautions for pancreatic cancer and cancerous neuromuscular disease Inappropriate people: People who are taking immunomedicine. Taboo before the test: taboo spicy dry food, affect blood testing, and taboo drug use. Requirements for inspection: Obey the doctor's request and do a good blood sample. Inspection process By detecting the structure of tumor-related genes, the defects and expression functions of tumor-related genes are analyzed to achieve the purpose of gene diagnosis of tumors. In the genetic diagnosis of tumors, PCR technology has the advantages of simple and rapid, high specificity, high sensitivity, and low requirements on sample DNA. Therefore, we used PCR-SSP method to analyze the relationship between CK-ras gene and Rb gene point mutation in pancreatic cancer specimens and pancreatic cancer, and to find a feasible method for early diagnosis of pancreatic cancer. Not suitable for the crowd People who are taking immunomedicine. Adverse reactions and risks Generally not.

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