Islet cell antibodies

Islet cell antibody (ICA) is a specific antibody that acts on the cytoplasmic component of islet cells and belongs to IgG immunoglobulin. ICA in serum can react with beta cells to produce cytotoxic effects. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: Normal: negative. Positive: It is used as an immune marker in the early stage of type 1 diabetes for early diagnosis. Tips: Try to eat less and eat as much as possible, and arrange your diet reasonably. Normal value negative. Clinical significance It is used as an immune marker in the early stage of type 1 diabetes for early diagnosis. Positive results may be diseases: pediatric diabetes, vulva black acanthosis considerations The insulin-dependent diabetes anti-islet cell antibody positive rate was 20% to 40%, the active positive rate was 60% to 70%; the non-insulin-dependent diabetes positive rate was only 6.2%. Therefore, detection of anti-islet cell antibodies can be classified into type 1 and type 2 diabetes. Inspection process The antigen sheet was soaked in PBS of pH 7.4, 0.01 mol/L, and the filter paper was blotted dry. The serum to be tested diluted with PBS for 1:5 was added, placed in a wet box at 37 ° C for 30 min, and washed with PBS three times for 5 min each time, and the fan was blown dry. The anti-human IgG fluorescent antibody was added dropwise, and the mixture was incubated at 37 ° C for 30 min, washed with the same method and dried. Check with a fluorescence microscope. Not suitable for the crowd There are no special taboos. Adverse reactions and risks There are no related complications and hazards.

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