Rheumatoid-associated nuclear antigen (RANA) antibodies

The positive rate of anti-RAN antibody in serum of RA patients is 93%-95%, which is significantly higher than that of other types of arthritis patients and about 16% of healthy people, and can be used as a strong evidence for diagnosis. RANA antibody detection rate and mean titer were significantly higher than normal human and other connective tissue diseases. The detection rate of RANA antibody in rheumatoid factor (RF) positive and negative RA patients was very close to the average titer. The results at home and abroad are similar. The detection rate of EBVCA-IgA, EBVEA-IgG antibody was significantly higher in patients with nasopharyngeal carcinoma (NPC) than in other diseases and normal people. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Rheumatoid arthritis. Tips: Do not wear clothes that are too small or too tight, so as to avoid the sleeves being too tight when blood is drawn or the sleeves are too tight after blood drawing, causing blood vessels in the arms. Normal value negative. Clinical significance Abnormal results were positive for rheumatoid arthritis. RANA antibody detection rate and mean titer were significantly higher than normal human and other connective tissue diseases. The detection rate of RANA antibody in rheumatoid factor (RF) positive and negative RA patients was very close to the average titer. The results at home and abroad are similar. The detection rate of EBVCA-IgA, EBVEA-IgG antibody was significantly higher in patients with nasopharyngeal carcinoma (NPC) than in other diseases and normal people. The same patient did not necessarily detect five EBV antibodies at the same time, but the detection rate of RANA antibody had no significant relationship with the course of RA patients, and the average titer of RANA antibodies was significantly increased in active RA. At the same time, peripheral blood T cell subsets were detected, and in patients with active RA, the percentage of T8 cells decreased, and the T〓/T〓 ratio increased, which was significantly different from normal and stable RA. Need to check the population suspected rheumatoid arthritis population. Positive results may be diseases: gout, gouty arthritis, discoid lupus erythematosus, connective tissue enteritis, Felty syndrome, phlegm syndrome, vaginal precautions Inappropriate people: generally no special population. Taboo before the examination: It is necessary to cooperate with the doctor to write the correct name, neat and tidy, to avoid confusion caused by the same name or similar names. With these in mind, blood draws are more convenient and faster, and you can better save yourself time for diagnosis. Requirements for inspection: Do not wear clothes that are too small or too tight in cuffs to avoid the sleeves being too tight when blood is drawn or the sleeves are too tight after blood drawing, causing blood vessels in the arms. Different laboratory items should be asked by the doctor and treated differently. Inspection process Five kinds of EBV antibodies, such as RANA, EBNA, EBVCA-IgA, EBVCA-IgG and EBVEA-IgG, were determined by indirect immunofluorescence, anti-complement indirect immunofluorescence and immunoenzymatic methods. We also focused on the relationship between RANA and DBEBNA using SDS-PAGE immunoblotting. The EBV-transformed Raji cells, wil-2 cell polypeptides were separated by SDS-PAGE electrophoresis, and then the cell polypeptide was transferred to a nitrocellulose membrane, and then subjected to enzyme-linked immunoreactivity with the serum to be tested, and EBNA1 single-shell clone antibody was simultaneously used. as comparison. Not suitable for the crowd There are no special taboos. Adverse reactions and risks There are no related complications and hazards.

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