anti-cardiomyocyte membrane antibody

Myocardial cell membranes can cause immune responses in patients with viral myocarditis and dilated cardiomyopathy, producing specific antibodies, which may direct the myocardial cell membrane to become autoantigens. Anti-myocardial membrane antibody (AMLA) has lytic cardiomyocyte function. Electron microscopy and cardiomyocyte immunofluorescence examination show that AMLA binds to the surface of myocardial cell membrane, and it can not cross-react with hepatocytes, only lytic effect on myocardial cells. And the dissolution of cardiomyocytes occurs only in the presence of complement. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: abnormal. Tips: After 8 pm on the day before the medical examination, you should start fasting for 12 hours, so as not to affect the test results. Normal value negative. Clinical significance The study found that patients with dilated cardiomyopathy after acute viral myocarditis and myocarditis contain AMLA in the serum, and the positive detection rate of AMLA in patients with stable dilated cardiomyopathy is 30% to 40%. Acute myocarditis and acute phase expansion The positive rate of AMLA in serum of patients with cardiomyopathy was significantly higher than that of patients with stable phase, indicating that serum AMLA is associated with myocarditis and dilated cardiomyopathy. Positive results may be diseases: pediatric rheumatic fever, neonatal myocarditis, dilated cardiomyopathy Inappropriate people: generally no special population. Contraindications before the examination: After 8 pm on the day before the medical examination, fasting should be started for 12 hours to avoid affecting the test results. Requirements for examination: doctors should pay attention to the study of immunoblotting in China. It is found that children with viral myocarditis account for about 1/4 of anti-ANT antibodies. If the patient has localized congestion, it can be absorbed after 24 hours with a warm towel. Inspection process Using classical indirect immunofluorescence assays (using human and rat heart tissue as antigenic tablets), colloidion particle agglutination test, antiglobulin consumption test, tannic acid treatment or hydroformylation red blood cell agglutination test And ELISA methods and immunoblotting techniques adopted in recent years. Not suitable for the crowd There are no special taboos. Adverse reactions and risks There are no related complications.

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