anti-thyroglobulin antibody

Anti-thyroglobulin antibody (ATG) was discovered by Roitt et al in 1958 in the serological study of autoimmune thyroiditis (Hashimoto thyroiditis, etc.). ATG's target antigen thyroglobulin (TG) is a soluble iodinated glycoprotein synthesized and secreted by thyroid epithelial cells, with a molecular weight of 660 kD and consisting of 2748 amino acids. It is a biosynthetic precursor of T3 (triiodothyronine, triiodothyronine), T4 (tet-raiodothyronine, tetrathymidine, thyroxine, thyroxine), which is mainly stored in colloidal form in thyroid filtration. In the vesicle, the content of normal human serum is extremely small (10-40 ng/ml). Witebsky et al. immunized rabbits with the same thyroid tissue to induce thyroiditis in rabbits similar to ATG and Hashimoto's thyroiditis. ATG is the most typical organ-specific antibody among human autoantibodies, mainly IgG, IgA is 20%, and IgM is 5%. Among the four subtypes of IgG with ATG activity, the proportion of IgG was significantly increased, about 6 times that of its normal proportion (5%). ATG can not bind to complement, which may be related to the high proportion of IgG4 subclasses. More importantly, the epitopes on thyroglobulin are separated far apart, and the antibody molecules bound to them cannot form cross-linking. Therefore. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: The detection rate of ATG in patients with Hashimoto thyroiditis can reach 90%-95%; the detection rate of hyperthyroidism patients ranges from 40% to 90%. Tips: Try to eat less and eat as much as possible, and arrange your diet reasonably. Normal value Healthy people ATG is negative. Clinical significance The detection rate of ATG in patients with Hashimoto thyroiditis can reach 90%-95%; the detection rate of hyperthyroidism patients varies from 40% to 90%. The high detection rate may be related to Hashimoto's hyperthyroidism in some cases. Related; the detection rate of patients with primary hypothyroidism is about 65%. The detection rates of subacute thyroiditis, thyroid cancer, and thyroid adenoma are very low. The detection rate of serum ATG in patients with connective tissue disease such as SLE is 20% to 30%. Patients with ATG-positive, especially high-level positive, should be cautious in their choice of treatment. A thyroid biopsy study of some patients with low ATG positives found that these patients had localized lymphocytic infiltration in the thyroid tissue. Precautions It has also been reported that 2% to 5% of normal people (mostly women) can detect ATG. Inspection process Indirect immunofluorescence. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.

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