anti-erythrocyte antibodies

Anti-erythrocyte antibody (RBC antibody) was first reported by Donatht and Landsteiner in 1904 and is the first elucidated autoantibody in humans, now known as the Donath-Landsteiner (DL) antibody. It is divided into three categories: warm antibody (WAS), cold agglutinin antibody (CAs), and DL antibody. This antibody causes autoimmune hemolytic anemia (AHA). Antiglobulin assays are used to detect anti-erythrocyte antibodies. Antiglobulin assays have direct and indirect direct antiglobulin assays for detecting antibodies on the surface of red blood cells; indirect antiglobulin assays are used to detect free anti-erythrocyte antibodies. The anti-erythrocyte antibodies of SLE and idiopathic autoimmune hemolytic anemia are warm antibodies, and most of the warm antibodies are IgG type. The most common type of cold antibody is the IgM type antibody, and SLE with hemolytic anemia is associated with cold antibodies. Anti-erythrocyte antibodies cause destruction of red blood cells and reduce the number of red blood cells. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Tips: According to the nutritional status of the whole body, milk, eggs, fruits, soy milk, etc. are given in the meal. Normal value negative. Clinical significance Positive autoimmune hemolytic anemia (AIHA), cold agglutinin disease, paroxysmal cold hemoglobinuria, acute idiopathic acquired hemolytic anemia (Lederer anemia), chronic idiopathic warm antibody immunological hemolytic anemia Symptomatic warm-type antibody immunological hemolytic anemia. Anti-erythrocyte antibodies are closely related to autoimmune hemolytic anemia and can be spontaneous, primary or secondary to other diseases. The secondary AIHA mostly showed autoimmune response to polyclonal antibody, which was associated with HLA-A1, A8 and B8. The pathogenesis of AIHA induced by anti-Cas and anti-DL was not clear. By detecting anti-RBC antibodies in combination with other hemolytic anemia indicators (such as elevated LDH, reticulocyte increase, haptoglobin reduction, etc.) to diagnose AIHA; red blood cell destruction caused by CAs and anti-DL antibodies can cause paroxysmal cold Hemoglobinuria (PCH); extensive infection is associated with Was induction, and Was is often detected in viral infections, especially in children with viral infections; 50% to 80% of mycoplasmal pneumonia, 30% to 50% of EBV-infected patients Cas can appear in it. Anti-BrRBC antibodies are associated with primary AIHA and hemolytic anemia caused by SLE, chronic lymphocytic leukemia, and hairy cell leukemia. Precautions Although the sensitivity of the antiglobulin test is not ideal, there are now more sensitive ELSA and radioimmunoassay, but the antiglobulin test is simple and practical, and is still clinically applied. Inspection process Same as ELISA and radioimmunoassay. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.

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