Allergen Screening

The allergen screening method is a method for screening allergens by means of an immunostaining method or an allergic reaction by inhaling a sensitizing substance by an allergen detection system. Basic Information Specialist classification: skin examination classification: immune examination Applicable gender: whether men and women apply fasting: not fasting Tips: Do not drink alcohol at the same time, or take sedative hypnotics and antidepressants. Normal value The antigen was negative. Clinical significance Abnormal result Skin allergies are also known as "sensitive" skin. Skin allergies mainly refer to cosmetics, chemicals, pollen, certain foods, polluted air, etc., which cause skin irritation, such as adverse reactions, resulting in abnormalities such as redness, itching, peeling and allergic dermatitis. Sensitive skin can be said to be an unstable skin, a skin that is always on high alert. Diseases caused by skin allergies in people who need to be examined include dermatitis, contact dermatitis, atopic dermatitis and other skin diseases. Precautions Taboo before inspection: 1. Do not drink alcohol at the same time during medication, or take sedative hypnotics and antidepressants. 2. The data on the teratogenic effects of H1 receptor antagonists on humans are not sufficient, but animal tests have been shown to cause cleft palate, inguinal hernia or urinary system malformation. Therefore, women in pregnancy should carefully weigh the pros and cons; while H1 receptor antagonism The agent is also secreted by milk, and should not be used for lactating women. Infants and the elderly should be used with caution. 3, H1 receptor antagonist drugs have low toxicity and a large safety range, but due to the wide application, acute poisoning of drugs can also occur, especially after children are poisoned by accidental poisoning. The most common symptoms of overdose are drowsiness, dizziness, and ataxia. Anticholinergic effects such as facial flushing, dilated pupils, and hyperthermia can occur within 2 hours. Central excitatory effects are mainly seen in children, manifested as hallucinations, toxic psychosis, etc., which can eventually cause convulsions. Adult acute poisoning usually undergoes a period of incubation, which can be followed by respiratory depression, cardiovascular depression, and even death. Heart rhythm disorders are rare. 4, pay attention to the application of special population: for allergic symptoms to the early morning, you can use long-acting antagonists to take before bedtime, both to relieve symptoms and avoid other adverse reactions. 5, pay attention to the time of administration: such as astemizole with food can reduce the bioavailability of this product, in order to ensure absorption, it is appropriate to take 1 to 2 hours before meals. 6, pay attention to avoid cardiotoxicity: should not be taken in excess, avoid using drugs that are known to interfere with the metabolism of liver drug enzymes. Excessive use (even normal recommended dose), hypokalemia, liver compensatory dysfunction or simultaneous use of liver enzyme P450 inhibitor drugs (eg ketoconazole, itraconazole, erythromycin, oleandomycin, carat Under the conditions of mycin, ciprofloxacin, cimetidine, etc., some second-generation H1 receptor antagonists (astemizole, terfenadine, ebastine) may inhibit cardiac potassium slow channel There is a risk of causing a torsade ventricular tachycardia or prolonged QT interval. Therefore, the dose should be strictly controlled, and the interaction of drugs should be paid attention to. At the same time, potassium and magnesium should be supplemented appropriately for those with low potassium concentration. Those with congenital QT syndrome should not be used. 7. During the medication, it should be forbidden to spicy or simmer food, avoid scratching the skin or hot water, and suspend the use of soap. Requirements for inspection: The hospital can check it, do not eat spicy foods such as spicy food. Inspection process 1. Do not drink alcohol at the same time during medication, or take sedative hypnotics and antidepressants. 2. The data on the teratogenic effects of H1 receptor antagonists on humans are not sufficient, but animal tests have been shown to cause cleft palate, inguinal hernia or urinary system malformation. Therefore, women in pregnancy should carefully weigh the pros and cons; while H1 receptor antagonism The agent is also secreted by milk, and should not be used for lactating women. Infants and the elderly should be used with caution. 3, H1 receptor antagonist drugs have low toxicity and a large safety range, but due to the wide application, acute poisoning of drugs can also occur, especially after children are poisoned by accidental poisoning. The most common symptoms of overdose are drowsiness, dizziness, and ataxia. Anticholinergic effects such as facial flushing, dilated pupils, and hyperthermia can occur within 2 hours. Central excitatory effects are mainly seen in children, manifested as hallucinations, toxic psychosis, etc., which can eventually cause convulsions. Adult acute poisoning usually undergoes a period of incubation, which can be followed by respiratory depression, cardiovascular depression, and even death. Heart rhythm disorders are rare. 4, pay attention to the application of special population: for allergic symptoms to the early morning, you can use long-acting antagonists to take before bedtime, both to relieve symptoms and avoid other adverse reactions. 5, pay attention to the time of administration: such as astemizole with food can reduce the bioavailability of this product, in order to ensure absorption, it is appropriate to take 1 to 2 hours before meals. 6, pay attention to avoid cardiotoxicity: should not be taken in excess, avoid using drugs that are known to interfere with the metabolism of liver drug enzymes. Excessive use (even normal recommended dose), hypokalemia, liver compensatory dysfunction or simultaneous use of liver enzyme P450 inhibitor drugs (eg ketoconazole, itraconazole, erythromycin, oleandomycin, carat Under the conditions of mycin, ciprofloxacin, cimetidine, etc., some second-generation H1 receptor antagonists (astemizole, terfenadine, ebastine) may inhibit cardiac potassium slow channel There is a risk of causing a torsade ventricular tachycardia or prolonged QT interval. Therefore, the dose should be strictly controlled, and the interaction of drugs should be paid attention to. At the same time, potassium and magnesium should be supplemented appropriately for those with low potassium concentration. Those with congenital QT syndrome should not be used. 7. During the medication, it should be forbidden to spicy or simmer food, avoid scratching the skin or hot water, and suspend the use of soap. Requirements for inspection: The hospital can check it, do not eat spicy foods such as spicy food. Not suitable for the crowd People with severe allergies. Adverse reactions and risks There are no related complications and hazards.

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