Cerebral oxygen metabolism imaging

Brain oxygen metabolism imaging Normal human brain weighs only 2% of the body weight, but its oxygen consumption accounts for 20% of the whole body. Therefore, brain oxygen consumption is an important reference index reflecting the functional metabolism of human brain. The patient's dynamic imaging of PET immediately after inhalation of 15O2 can obtain the cerebral oxygen metabolism rate (CMRO2), and the oxygen uptake score (OEF) can be calculated in combination with the CBF measurement. After 15O2 is inhaled by the subject, it participates in the whole process of oxygen metabolism, and dynamic imaging with PET can obtain the cerebral oxygen metabolism rate (CMRO2). Combined with the CBF measurement results, the oxygen uptake score (OEF) of the human brain can also be calculated, and the formula is OEF=CMRO2/CBF. Basic Information Specialist Category: Inspection Category: CT Applicable gender: whether men and women apply fasting: not fasting Tips: Check the fasting, ban on alcohol, banned drinking sugary drinks, and ban intravenous drip of glucose at 9:00 on the night before the check. Drink a small amount of water. Remove the metal ornaments (such as belts, keys, jewelry, coins, etc.) worn on the body before imaging; drain the urine before the imaging (be careful not to stain the clothes or skin with urine to avoid misdiagnosis). Normal value The reference value of gray matter CMRO2 is 259 (mol/(100 g.min), and the white matter is 80 (mol/(100 g.min); the OEF reference values ​​of gray matter and white matter are 0.49 and 0.48, respectively. Clinical significance Abnormal results Diagnosis and differential diagnosis of neuropsychiatric diseases such as schizophrenia, depression, Alzheimer's disease, epilepsy and Parkinson's disease based on image acquisition and data processing results. People with neuropsychiatric diseases such as schizophrenia, depression, Alzheimer's disease, epilepsy, and Parkinson's disease need to be examined. Precautions Taboo before inspection: 1. Drinking water: 30 minutes after the injection of 18F-FDG, drinking 3-4 cups, about every 10 minutes; 2. Remove the metal ornaments (such as belts, keys, necklaces, jewelry, coins, etc.) worn by the body before imaging; 3, before the imaging is exhausted in the urine (be careful not to contaminate the clothes or skin, so as not to misdiagnose); 4. The examinee started fasting, banned alcohol, banned drinking sugary drinks, banned intravenous drip of glucose, and banned from vigorous or prolonged exercise at 9:00 pm on the day before the examination. Drink a small amount of water; 5, check the day to avoid talking with people, do not chew gum, etc.; avoid stressful position; 6. When you come to the PET/CT center, please bring along the relevant information (medical records, treatment records, pathological results, imaging examination data such as CT, X-ray, MRI, DSA, B-ultrasound, bone imaging, etc.). Requirements for inspection: 1. Keep quiet before and after injection of imaging drugs, and rest in a lying position or a semi-recumbent position, try to avoid walking; 2, need to calmly breathe during the examination, it is not appropriate to take a deep breath; some subjects need to hold their breath for a few seconds (according to the doctor's advice); 3, keep the position does not move, the best hands to lift the whole body examination, check about 15 ~ 20min; brain examination does not require hands to lift, check about 5 ~ 10min. Inspection process After 15O2 is inhaled by the subject, it participates in the whole process of oxygen metabolism, and dynamic imaging with PET can obtain the cerebral oxygen metabolism rate (CMRO2). Combined with the CBF measurement results, the oxygen uptake score (OEF) of the human brain can also be calculated, and the formula is OEF=CMRO2/CBF. Not suitable for the crowd Inappropriate people: pregnant women, emotional instability or persistent sputum are banned.

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