Brain Protein Metabolism Imaging

Brain protein metabolism imaging utilizes 11C-MET (11C-methyl-L-methionine), 11C-TYR (11C-tyrosine), 18F-FET (18F-fluoroethyl tyrosine), and 123I-IMT ( 123I-iodomethyltyrosine) can be used as an imaging agent to obtain an image reflecting the function of amino acid uptake and protein synthesis in the brain. Subjects were fasted for 4 to 8 hours before the examination, and closed with earplugs and black eye masks for 15 minutes. Intravenous injection of 11C-MET (11C-methyl-L-methionine), 11C-TYR (11C-tyrosine), 18F-FET (18F-fluoroethyl tyrosine) and 123I-IMT (123I-iodine) After methyl tyrosine), the imaging was performed after a quiet rest for 45 minutes. Basic Information Specialist Category: Inspection Category: CT Applicable gender: whether men and women apply fasting: fasting Tips: Check the fasting, ban on alcohol, banned drinking sugary drinks, and ban intravenous drip of glucose at 9:00 on the night before the check. Drink a small amount of water; remove the metal accessories (such as belts, keys, jewelry, coins, etc.) worn by the body before imaging; drain the urine before the imaging (be careful not to stain the clothes or skin with urine to avoid misdiagnosis) . Normal value The amino acid uptake and protein synthesis functions in the brain are normal. Clinical significance Abnormal results Diagnosis of neuropsychiatric disorders such as schizophrenia, bipolar depression, unipolar depression, dementia, Huntington's chorea, and Parkinson's disease based on image acquisition and data processing results. People with neuropsychiatric disorders such as schizophrenia, bipolar depression, unipolar depression, dementia, Huntington's disease, and Parkinson's disease need to be examined. Precautions Taboo before inspection: 1. Drinking water: 30 minutes after the injection of 18F-FDG, drinking 3-4 cups, about every 10 minutes; 2. Remove the metal ornaments (such as belts, keys, necklaces, jewelry, coins, etc.) worn by the body before imaging; 3, before the imaging is exhausted in the urine (be careful not to contaminate the clothes or skin, so as not to misdiagnose); 4. The examinee started fasting, banned alcohol, banned drinking sugary drinks, banned intravenous drip of glucose, and banned from vigorous or prolonged exercise at 9:00 pm on the day before the examination. Drink a small amount of water; 5, check the day to avoid talking with people, do not chew gum, etc.; avoid stressful position; 6. When you come to the PET/CT center, please bring along the relevant information (medical records, treatment records, pathological results, imaging examination data such as CT, X-ray, MRI, DSA, B-ultrasound, bone imaging, etc.). Requirements for inspection: 1. Keep quiet before and after injection of imaging drugs, and rest in a lying position or a semi-recumbent position, try to avoid walking; 2, need to calmly breathe during the examination, it is not appropriate to take a deep breath; some subjects need to hold their breath for a few seconds (according to the doctor's advice); 3, keep the position does not move, the best hands to lift the whole body examination, check about 15 ~ 20min; brain examination does not require hands to lift, check about 5 ~ 10min. Inspection process Imaging agent Commonly used imaging agents are 11C-MET (11C-methyl-L-methionine), 11C-TYR (11C-tyrosine), 18F-FET (18F-fluoroethyl tyrosine) and 123I-IMT (123I) - Iodomethyl tyrosine), intravenously. 2. Operating procedures Subjects were fasted for 4 to 8 hours before the examination, and closed with earplugs and black eye masks for 15 minutes. Intravenous injection of 11C-MET (11C-methyl-L-methionine), 11C-TYR (11C-tyrosine), 18F-FET (18F-fluoroethyl tyrosine) and 123I-IMT (123I-iodine) After methyl tyrosine), the imaging was performed after a quiet rest for 45 minutes. The subject took the supine position and placed the head in the head rest. The fixed head kept the position unchanged during the whole examination. 3. Image acquisition and data processing The acquisition matrix is ​​128×128. A filtered back projection reconstruction method is employed and attenuation correction is performed. The layer thickness is 4mm. Not suitable for the crowd Inappropriate people: pregnant women, emotional instability or persistent sputum are banned.

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