Brain Glucose Metabolism Imaging

Neuropsychiatric activity is accompanied by energy metabolism, so the physiological function and pathological state of human brain can be studied by FDG-PET imaging. The application of cerebral glucose metabolism imaging makes the first non-invasive observation in human history in the living and listening. Changes in regional cerebral glucose metabolism (LCMRGlu) in the specific functional areas of the central nervous system under behavioral and psychological activities such as thinking, memory, and schizophrenia, bipolar depression, unipolar depression, dementia, and Huntington dance. The characteristics of LCMRGlu changes in neuropsychiatric diseases such as diseases and Parkinson's disease, and the application value of brain glucose metabolism imaging in the nervous system are gradually recognized by clinical and scientific researchers. Basic Information Specialist Category: Inspection Category: CT Applicable gender: whether men and women apply fasting: not fasting Tips: Check the fasting, ban on alcohol, banned drinking sugary drinks, and ban intravenous drip of glucose at 9:00 on the night before the check. Drink a small amount of water. Normal value Normal brain glucose metabolism images are similar to cerebral blood perfusion images. The normal reference value of cerebral glucose metabolic rate CMRGlu is 20~50μmol/(100g.min), and there are some differences in LCMRGlu in each region. LCMRlu in both cerebral hemispheres is 37.6±8.67μmol/(100g.min) and 37.11±8.72μmol/( 100g.min). Clinical significance Abnormal results Diagnosis of neuropsychiatric disorders such as schizophrenia, bipolar depression, unipolar depression, dementia, Huntington's chorea, and Parkinson's disease based on image acquisition and data processing results. People with neuropsychiatric disorders such as schizophrenia, bipolar depression, unipolar depression, dementia, Huntington's disease, and Parkinson's disease need to be examined. Precautions Taboo before inspection: 1. Drinking water: 30 minutes after the injection of 18F-FDG, drinking 3-4 cups, about every 10 minutes; 2. Remove the metal ornaments (such as belts, keys, necklaces, jewelry, coins, etc.) worn by the body before imaging; 3, before the imaging is exhausted in the urine (be careful not to contaminate the clothes or skin, so as not to misdiagnose); 4. The examinee started fasting, banned alcohol, banned drinking sugary drinks, banned intravenous drip of glucose, and banned from vigorous or prolonged exercise at 9:00 pm on the day before the examination. Drink a small amount of water; 5, check the day to avoid talking with people, do not chew gum, etc.; avoid stressful position; 6. When you come to the PET/CT center, please bring along the relevant information (medical records, treatment records, pathological results, imaging examination data such as CT, X-ray, MRI, DSA, B-ultrasound, bone imaging, etc.). Requirements for inspection: 1. Keep quiet before and after injection of imaging drugs, and rest in a lying position or a semi-recumbent position, try to avoid walking; 2, need to calmly breathe during the examination, it is not appropriate to take a deep breath; some subjects need to hold their breath for a few seconds (according to the doctor's advice); 3, brain examination does not require hands flat, check about 5 ~ 10min. Inspection process Imaging agent The commonly used imaging agent is 18F-FDG, the dosage is 370MBq (10mCi) / 1ml, intravenous injection. 2. Operating procedures Subjects were fasted for 4 to 8 hours before the examination, and closed with earplugs and black eye masks for 15 minutes. After intravenous injection of 18F-FDG, the imaging was performed after a quiet rest for 45 minutes. The subject took the supine position and placed the head in the head rest. The fixed head kept the position unchanged during the whole examination. 3. Image acquisition and data processing The acquisition matrix is ​​128×128. A filtered back projection reconstruction method is employed and attenuation correction is performed. The layer thickness is 4mm. 4. Normal image Normal brain glucose metabolism images are similar to cerebral blood perfusion images. The normal reference value of cerebral glucose metabolic rate CMRGlu is 20~50μmol/(100g.min), and there are some differences in LCMRGlu in each region. LCMRlu in both cerebral hemispheres is 37.6±8.67μmol/(100g.min) and 37.11±8.72μmol/( 100g.min). Not suitable for the crowd Inappropriate people: pregnant women, emotional instability or persistent sputum are banned.

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