Plasma cell

The plasma cells are elliptical and have a diameter of 8 to 20 μm. The nucleus is round and obviously eccentric. The purple-red chromatin is a coarse clot and arranged in a wheel shape (in the case of pathology, there may be 2 to 4 nuclei in a cell). The cytoplasm is rich, gray-blue, and some are lilac-colored, sometimes there are many vacuoles, and there may be a little azure particles. There is a distinct semicircular blank area near the core. In addition, occasionally, multiple layers are formed in the cytoplasm, and the endoplasmic reticulum in the cytoplasm is expanded, broken or rounded. Finally, vacuoles are formed, and the vacuoles are seen to increase from small to large on the smear. Until the process of becoming a large vacuole, and seeing the various transitional cells containing these vacuoles, these denatured cells are eventually swallowed by macrophages. This cell increases during aplastic anemia. In addition, plasma cells and larvic cells can also appear in the blood due to antigenic stimulation or certain infectious diseases, especially in the case of rubella, which can have a wide variety of plasma cells. In the case of infectious mononucleosis, epidemic hemorrhagic fever, toxoplasmosis, syphilis, tuberculosis, etc., plasma cells may appear in the blood. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Adjust the diet before the test, pay attention to the schedule, adjust the body to the most normal state. Normal value no. Clinical significance Abnormal results: a disorder of plasma cell proliferation, manifested as a series of pathological and biochemical changes. The cause is unknown and may be related to genetic and viral infections. People who need to be tested: intestinal cancer, biliary tract cancer, breast cancer, kidney cancer, complicated by chronic infections, such as osteomyelitis, tuberculosis, rheumatoid arthritis, to find the cause can start from plasma cells. Precautions Before the test: adjust the diet, pay attention to the schedule, adjust the body to the most normal state. When checking: Relax as much as possible to eliminate tension. Inspection process Commonly used inspection methods are: 1 serum total protein amount. A refractometer can be used to measure whether the total amount of protein in the serum is increased (including Ig). 2 serum protein electrophoresis. The patient's serum is placed in a cellulose acetate or agarose medium and the pH is adjusted to 8.2 to 8.6. After electrification, all serum proteins except for IgG are negatively charged and migrate toward the anode, while IgG stays in place or moves toward the cathode. According to the different speeds of various proteins, the components are separated and dyed with protein-binding dyes to identify the five parts of albumin and globulin β and γ. 3 immunoelectrophoresis. Analysis of various proteins separated by electrophoresis can be carried out by immunoprecipitation. The patient's serum is subjected to protein electrophoresis, and then multivalent antiserum (the serum after immunizing the experimental animal with normal human serum) is dispersed into the electrophoresis line, and a series of precipitation lines can be formed to identify various Ig. Not suitable for the crowd No taboos. Adverse reactions and risks No complications.

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