Tests reflecting changes in liver interstitium

The serum protein electrophoresis that reflects the changes of liver interstitial has basically replaced the flocculation reaction. The degree of γ-globulin increase can evaluate the evolution and prognosis of chronic liver disease, suggesting that Kupffer cells are dysfunctional and cannot eliminate endogenous or Enterogenous antigenic substance. In addition, the serum levels of hyaluronic acid, lamellar, type III procollagen peptide and type IV collagen reflect changes in liver endothelial cells, fat storage cells and fibroblasts, and are closely related to liver fibrosis and cirrhosis. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: not fasting Tips: Do not eat before the test, blood test requires fasting, fasting time is generally 8 to 12 hours. Normal value GLB (globulin) normal value 22-38g / L. HA (hyaluronidase) normal value 50-180 ng / mL. Clinical significance Abnormal results The degree of gamma-globulin elevation can be evaluated for the evolution and prognosis of chronic liver disease, suggesting that Kupffer cells are hypofunction. Blood HA was higher than 100 μg / L, indicating the presence of cirrhosis and liver fibrosis. Need to check patients with impaired liver function. High results may be diseases: liver fibrosis, cirrhosis considerations Taboo before inspection: 1. Be careful not to take the drug before the test, because some drugs will increase the burden on the liver, causing temporary damage to the liver function, which will lead to the accuracy of the liver function test results. 2. Pay attention to ensure adequate sleep before exercise, do not exercise vigorously, which may cause elevated transaminase, thus affecting the test results. 3. You must not drink alcohol the day before. Drinking alcohol will cause an increase in transaminase and affect the test results. 4. Do not eat greasy food the day before. Taboo during the examination: can not eat before the examination, blood test requires fasting, fasting time is generally 8 to 12 hours. Inspection process 6 ml of venous blood was drawn, and it was packed in a common tube, and the globulin and hyaluronic acid concentration values ​​were examined separately. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., because the drug will increase the burden on the liver, may affect the results of the examination, and prohibit patients with a history of drug administration in the near future. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.

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