blocking antibody test

In the serum of normal pregnant women, there is a specific IgG antibody against spouse lymphocytes, which can inhibit lymphocyte reaction (MLR), block the cytotoxic effect of maternal lymphocytes on the cultured trophoblast, and prevent helper T cells from recognizing the fetus. An inhibitor of the antigen and can prevent the mother's immune system from attacking the embryo. Blocking alloantigen-stimulated lymphocytes produces macrophage migration inhibitory factor (MIF), so it is called blockingantibodies (BA). A closed antibody test is to check whether the pregnant woman's serum contains such antibodies. Basic Information Specialist classification: gynecological examination classification: immune examination Applicable gender: whether women are fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Repeated spontaneous abortions often occur with no blocking antibodies. Positive: There is a blocking antibody present in the serum of normal pregnant women. Tips: In the morning, blood is collected on an empty stomach. Coffee, tea, high sugar and cola drinks should be fasted. Normal value There is a blocking antibody present in the serum of normal pregnant women. Clinical significance Abnormal result The absence of a blocked antibody results in repeated spontaneous abortions. People who need to be checked Repeated spontaneous abortion patients. Positive results may be diseases: complete abortion precautions Taboo before inspection: 1. Blood is collected on an empty stomach in the morning. Coffee, tea, high sugar and cola beverages should be fasted. 2, if there is a history of halo, fainting, please inform the blood collection nurse, in order to take preventive measures. Requirements for inspection: 1. Collect blood in a calm state to avoid emotional excitement. 2, if the test is negative, it needs to be positive after treatment and can be pregnant. It needs to continue treatment for three cycles after pregnancy. Inspection process There are several types of blocking antibodies: 1. Anti-war B cell antibody: an anti-fetal B lymphocyte surface HLA-D/DR antibody; 2, anti-cold B cell antibody: non-HLA cold B antibody; 3. Anti-specific antibodies: gene antibodies to the HLA-D/DR receptor on the surface of maternal helper T cells; 4, anti-TLX antibody: is an antibody against the common antigen of villus and lymphocytes, can block mixed lymphocyte reaction; 5. An antibody against an Fc receptor: a non-cellular barrier antibody that blocks an Fc receptor on a husband's B lymphocyte; 6. Anti-parental complement-dependent antibody (APCA). Mechanism of action of blocking antibodies: In vitro studies have shown that the mother can produce sensitized T cells during pregnancy, which can destroy the blast cells. However, the killing function of sensitized T cells can be inhibited by sexual antibodies. However, about 80%-90% of women with habitual abortion cannot detect this specific blocking antibody, and there are uninhibited cytotoxic cells in the body. These cells can act directly on the embryo or indirectly damage the fetus or placenta by releasing inflammatory mediators, leading to miscarriage. After the blood was collected, the serum was separated and a blocking antigen was added for examination. Not suitable for the crowd 1. Patients who have taken thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.

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